TYPHOID-FEVER - STUDIES OF BLOOD-COAGULATION, BACTEREMIA, AND ENDOTOXEMIA
TYPHOID-FEVER - STUDIES OF BLOOD-COAGULATION, BACTEREMIA, AND ENDOTOXEMIA
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DOI：
10.1001/archinte.138.3.407
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
ARNOLD, K
中科院分区：
文献类型：
--
作者：
BUTLER, T;BELL, WR;ARNOLD, K
研究人员对伤寒患者进行了研究，以确定弥散性血管内凝血（DIC）、循环细菌和内毒素血症是否是导致其疾病体征和症状的原因。 28 名患者的凝血检测结果显示，17 名患者出现血小板减少症，9 名患者出现低纤维蛋白原血症，20 名患者的纤维蛋白原相关抗原滴度升高。恢复期的重复检测显示其恢复至正常值。肠出血与凝血试验异常无关。 DIC 常见，但在这些患者中似乎是亚临床事件。在 25 名伤寒沙门氏菌血培养呈阳性的患者中，定量培养检测结果为 < 10 至 9 次。 102 个细菌/毫升。所有 21 名接受测试的患者的血浆内毒素检测均为阴性。伤寒中循环细菌和内毒素的浓度可能低于其他革兰氏阴性细菌感染。循环细菌和内毒素可能在伤寒的发病机制中不起主要作用。
Patients with typhoid fever were studied to determine whether disseminated intravascular coagulation (DIC), circulating bacteria and endotoxemia were responsible for the signs and symptoms of their illnesses. Coagulation tests in 28 patients detected thrombocytopenia in 17, hypofibrinogenemia in 9 and elevated titers of fibrinogen-related antigens in 20. Repeated testing during convalescence showed a return toward normal values. Intestinal bleeding did not correlate with abnormalities of coagulation tests. DIC occurred commonly but appeared to be a subclinical event in these patients. In 25 patients with positive blood cultures for Salmonella typhi, quantitative cultures detected from < 10 to 9 .times. 102 bacteria/ml. Limulus tests for endotoxin in plasma were negative in all 21 patients tested. The concentrations of circulating bacteria and endotoxin in typhoid fever maybe lower than in other gram-negative bacterial infections. Circulaing bacteria and endotoxin may not play a major role in the pathogenesis of typhoid fever.