Functional optical coherence tomography: principles and progress.
Functional optical coherence tomography: principles and progress.
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DOI：
10.1088/0031-9155/60/10/r211
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发表时间：
2015-05-21
影响因子：
3.5
通讯作者：
Wax A
中科院分区：
文献类型：
--
作者：
Kim J;Brown W;Maher JR;Levinson H;Wax A
在过去的十年中，出现了光学相干断层扫描（OCT）的几种功能扩展，本次综述重点介绍了这些扩展在仪器、理论分析、信号处理和临床应用方面的关键进展。我们回顾了五个主要扩展：多普勒 OCT (DOCT)、偏振敏感 OCT (PS-OCT)、光学相干弹性成像 (OCE)、光谱 OCT (SOCT) 和分子成像 OCT。前三者已通过离体和体内人体组织的研究得到进一步发展。本综述强调了 SOCT 和分子成像 OCT 的新技术，这些技术显示出巨大的临床应用潜力，但尚未在文献中得到充分评价。 SOCT 通过检测组织中波长依赖性的光吸收和散射来阐明组织特征，例如氧合作用和致癌作用。 SOCT 测量内源性生化分布，而分子成像 OCT 则检测外源性分子造影剂。功能性 OCT 的这些新进展提供了了解组织活动的新方法，这是当前其他成像方法无法实现的，从而拓宽了 OCT 的潜在临床应用。
In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the literature. SOCT elucidates tissue characteristics, such as oxygenation and carcinogenesis, by detecting wavelength-dependent absorption and scattering of light in tissues. While SOCT measures endogenous biochemical distributions, molecular imaging OCT detects exogenous molecular contrast agents. These newer advances in functional OCT broaden the potential clinical application of OCT by providing novel ways to understand tissue activity that cannot be accomplished by other current imaging methodologies.