Childhood asthma and smoking exposures before conceptionA three-generational cohort study
Childhood asthma and smoking exposures before conceptionA three-generational cohort study
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DOI：
10.1111/pai.12883
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发表时间：
2018-06-01
影响因子：
4.4
通讯作者：
Forsberg, Bertil
中科院分区：
文献类型：
--
作者：
Braback, Lennart;Lodge, Caroline J.;Forsberg, Bertil
研究背景最近的一些人类和动物研究表明，外祖母在怀孕期间吸烟会增加孙辈患哮喘的风险。我们已经调查了暴露的父母和/或孙子的性别是否修改祖母吸烟和孙子asthen.MethodsWe之间的关联形成了一个队列研究的基础上链接的国家登记处与前瞻性收集的数据超过三代。自1982年以来对怀孕早期吸烟习惯进行了登记，自2005年以来对购买处方药进行了登记。从2005年开始，共有10329名婴儿获得了母亲和祖父母双方吸烟的信息，并从出生到6岁进行了随访。购买药物时的年龄被用来将队列分为从未，早期短暂（0- 3岁），早期持续性（0-3岁和4- 6岁）和晚发型结果在校正母亲吸烟和其他混杂因素后，外祖母吸烟与早期持续性哮喘的几率增加有关（比值比1.29，95%置信区间1.10-1.51）。孙子性别没有改变这种关联。父亲的祖母的吸烟与任何哮喘phenotypes.ConclusionMaternal，但不是父亲接触到尼古丁前的概念是与早期持续性儿童哮喘的风险增加，但不是其他哮喘表型。我们的研究结果可能是一致的性别特异性模式的表观遗传转移。
BackgroundSome human and animal studies have recently shown that maternal grandmother's smoking during pregnancy increases the risk of asthma in the grandchildren. We have investigated whether sex of the exposed parent and/or grandchild modifies the association between grandmaternal smoking and grandchild asthma.MethodsWe formed a cohort study based on linkage of national registries with prospectively collected data over three generations. Smoking habits in early pregnancy were registered since 1982 and purchases of prescribed medication since 2005. In all, 10329 children born since 2005 had information on maternal and grandmaternal smoking on both sides and were followed from birth up to 6years of age. Ages when medication was purchased were used to classify the cohort into never, early transient (0-3years), early persistent (0-3 and 4-6years), and late-onset (4-6years) phenotypes of childhood asthma.ResultsMaternal grandmother's smoking was associated with an increased odds of early persistent asthma after adjustment for maternal smoking and other confounders (odds ratio 1.29, 95% confidence interval 1.10-1.51). Grandchild sex did not modify the association. Paternal grandmother's smoking was not associated with any of the asthma phenotypes.ConclusionMaternal but not paternal exposure to nicotine before conception was related to an increased risk of early persistent childhood asthma, but not other asthma phenotypes. Our findings are possibly consistent with a sex-specific mode of epigenetic transfer.