The Application of Metabolomic Profiling to the Effects of Physical Activity
The Application of Metabolomic Profiling to the Effects of Physical Activity
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DOI：
10.2174/2213235x03666150211000831
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Watson, David G.
中科院分区：
文献类型：
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作者：
Daskalaki, Evangelia;Easton, Chris;Watson, David G.
身体活动和锻炼是有效的生活方式干预措施，可减少几种身心风险，包括心血管疾病、糖尿病和轻度至中度抑郁症。目前的综述描述了1999-2014年期间主要健康受试者（N: 64）和2011-2014年期间一小部分患者队列（N: 10）中使用代谢组学/代谢物分析方法结合运动的研究。在健康和患者队列中使用了广泛的干预类型，采用了不同的运动方案，有或没有补充使用。对嘌呤代谢的影响，人们已经知道了40多年，这是迄今为止被引用最多、最持久的发现。其他报道的影响包括：糖皮质激素和雄激素代谢、糖酵解和克雷布斯循环、糖异生、脂肪酸代谢、脂肪酸氧化和泛酸、氨基酸氧化、色氨酸代谢和对微生物代谢产物的影响。讨论部分从非常不同的研究中得出观察结果，并将它们与人类新陈代谢的一般方面联系起来。
Physical activity and exercise are potent lifestyle interventions for the reduction of several psycho-somatic risks, including cardiovascular disease, diabetes and mild-to-moderate depression. The current review describes the studies which have utilised a metabolomics/metabolite profiling approach in combination with exercise in the period between 1999-2014 in predominantly healthy subjects (N: 64) and in a smaller subset of patient cohorts (N: 10) between 2011-2014. A broad range of intervention types were used in both healthy and patient cohorts with varying exercise regimes with or without supplement use. Effects on purine metabolism, which have been known for over 40 years, were by far the most well-cited and persistent finding. Other reported effects included observations of: glucocorticoid and androgen metabolism, glycolysis and Krebs cycle, gluconeogenesis, fatty acid metabolism, fatty acid oxidation and pantothenic acid, amino acid oxidation, tryptophan metabolism and effects on microbiome metabolites. The discussion section draws observations from the very disparate studies together and links them to the general aspects of human metabolism.