Influence of in vitro susceptibility phenotype against thrombin-induced platelet microbicidal protein on treatment and prophylaxis outcomes of experimental Staphylococcus aureus endocarditis
Influence of in vitro susceptibility phenotype against thrombin-induced platelet microbicidal protein on treatment and prophylaxis outcomes of experimental Staphylococcus aureus endocarditis
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DOI：
10.1086/315063
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发表时间：
1999-11-01
影响因子：
6.4
通讯作者：
Bayer, AS
中科院分区：
文献类型：
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作者：
Dhawan, VK;Yeaman, MR;Bayer, AS
凝血酶诱导的血小板杀微生物蛋白-1（tPMP-1）是来自兔血小板的一种小的阳离子葡萄球菌肽。在本研究中，在由tPMP-1体外敏感性（tPMP（S））或耐药性（tPMP（R））不同的同基因金黄色葡萄球菌菌株对（分别为ISP 479 C和ISP 479 R）引起的实验性感染性心内膜炎（IE）中，比较了万古霉素治疗和预防的结局。与对照组相比，万古霉素治疗（因其固有的缓慢杀菌活性而被选择）降低了赘生物中的ISP 479 C（而不是ISP 479 R）密度（P
Thrombin-induced platelet microbicidal protein-1 (tPMP-1) is a small, cationic staphylocidal peptide from rabbit platelets. In the current study, the outcomes of vancomycin treatment and prophylaxis were compared in experimental infective endocarditis (IE) caused by an isogenic Staphylococcus aureus strain pair differing in tPMP-1 susceptibility (tPMP(S)) or resistance (tPMP(R)) in vitro (ISP479C and ISP479R, respectively). Vancomycin therapy (selected for its intrinsically slow bactericidal activity) reduced ISP479C (but not ISP479R) densities in vegetations compared with controls (P