Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion.
Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion.
复制标题
中性粒细胞与淋巴细胞的比例与更广泛、严重和复杂的冠状动脉疾病以及心肌灌注受损有关。
DOI：
10.5543/tkda.2014.18949
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
H. F. Töre
中科院分区：
文献类型：
--
作者：
A. Tanındı;A. Erkan;B. Ekici;A. Alhan;H. F. Töre
目标
我们研究了中性粒细胞与淋巴细胞比值（N/L）与冠状动脉疾病（CAD）的范围、严重程度和复杂性以及心肌灌注的关系。
研究设计
151例接受冠状动脉造影的稳定型心绞痛（SAP）（n=93）或急性冠状动脉综合征（ACS）（n=58）患者纳入本研究。在冠状动脉造影前抽取血样。采用Gensini和SYNTAX评分及心肌发红分级（MBG）进行评价。
结果
SAP和ACS组的神经细胞计数分别为4.4±1.4和5.0±1.6（p=0.018），而淋巴细胞计数分别为2.2±0.7和2.1±0.7（p=0.104）。SAP组的N/L为2.2±1.2，ACS组为2.6±1.0（p=0.002）。在SAP患者中，N/L与Gensini和SYNTAX评分显著相关（Gensini评分r=0.32，p=0.002; SYNTAX评分r=0.36，p=0.000），但N/L与MBG无显著相关性。在ACS组中，N/L与Gensini和SYNTAX评分的相关性更强（Gensini r=0.42，p=0.001; SYNTAX r=0.51，p=0.000）。ACS患者N/L与MBG呈负相关（r=-0.48，p =0.000）。在校正年龄、糖尿病、高脂血症和他汀类药物使用后，SAP和ACS组的相关性仍然显著;然而，相关性较弱。根据SYNTAX评分，预测中度至重度CAD的临界值N/L为2.26，敏感性为72%，特异性为71%（曲线下面积[AUC]：0.772，95%置信区间[CI]：0.679-0.865，p<0.001）。
结论
N/L与严重、广泛和复杂的CAD相关，可用于预测CAD患者的中度至重度受累。
OBJECTIVES
We investigated the relation between neutrophil to lymphocyte ratio (N/L) and the extent, severity, and complexity of coronary artery disease (CAD) and myocardial perfusion.
STUDY DESIGN
One hundred and fifty-one patients who underwent coronary angiography with stable angina pectoris (SAP) (n=93) or acute coronary syndrome (ACS) (n=58) were included in the study. Blood samples were drawn before coronary angiography. Gensini and SYNTAX scores and myocardial blush grade (MBG) were assessed.
RESULTS
Neutrophil counts were 4.4±1.4 and 5.0±1.6 in the SAP and ACS groups (p=0.018), whereas lymphocyte counts were 2.2±0.7 and 2.1±0.7, respectively (p=0.104). N/L was 2.2±1.2 in the SAP and 2.6±1.0 in the ACS (p=0.002) groups. In patients with SAP, N/L was significantly correlated with Gensini and SYNTAX scores (Gensini score r=0.32, p=0.002; SYNTAX score r=0.36, p=0.000), but there was no significant correlation between N/L and MBG. In the ACS group, N/L had a more powerful association with both Gensini and SYNTAX scores (Gensini r=0.42, p=0.001; SYNTAX r=0.51, p=0.000). N/L was negatively correlated with MBG in ACS patients (r= -0.48, p=0.000). Significant correlations persisted both in the SAP and ACS groups after correcting for age, diabetes, hyperlipidemia, and statin use; however, the associations were weaker. Cut-off N/L to predict moderate to severe CAD according to SYNTAX score was 2.26, with 72% sensitivity and 71% specificity (area under the curve [AUC]: 0.772, 95% confidence interval [CI] 0.679-0.865, p<0.001).
CONCLUSION
N/L is associated with severe, extensive and complex CAD and may be used to predict moderate to severe involvement in patients with CAD.
影响因子：
158.5
作者：
Serruys, Patrick W.;Morice, Marie-Claude;Mohr, Friedrich W.
通讯作者：
Mohr, Friedrich W.