Norepinephrine inhibition in juvenile male zebra finches modulates adult song quality.

Norepinephrine inhibition in juvenile male zebra finches modulates adult song quality.
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DOI:
10.1016/j.brainresbull.2012.10.010
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发表时间:
2013-01
影响因子:
3.8
通讯作者:
Tang YP
Tang YP
中科院分区:
医学3区
文献类型:
--
作者:
Wade J;Lampen J;Qi L;Tang YP

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在发育过程中,雄性斑胸草雀学会了一种歌曲,最终用于求爱和保卫巢穴。去甲肾上腺素(NE)对脊椎动物的学习和记忆很重要,这种神经调节剂及其受体存在于控制歌曲学习和产生的整个大脑区域。本研究使用神经毒素N-(2-氯乙基)-N-乙基-2-溴苄胺盐酸盐(DSP 4),以减少青少年男性的脑NE水平。这种操纵抑制了高质量歌曲的发展,一些鸟类产生的音节异常长和/或包含的频率主要高于正常。这些结果表明,NE是重要的获得典型的歌曲。
During development, male zebra finches learn a song that they eventually use in courtship and defense of nest sites. Norepinephrine (NE) is important for learning and memory in vertebrates, and this neuromodulator and its receptors are present throughout the brain regions that control song learning and production. The present study used the neurotoxin N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP4) to reduce brain levels of NE in juvenile males. This manipulation inhibited the development of quality songs, with some birds producing syllables that were unusually long and/or contained frequencies that were predominantly higher than normal. These results suggest that NE is important for the acquisition of typical song.
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