Distinct mechanisms determine organ left-right asymmetry patterning in an uncoupled way
Distinct mechanisms determine organ left-right asymmetry patterning in an uncoupled way
复制标题
不同的机制以非耦合的方式决定器官左右不对称模式。
DOI：
10.1002/bies.201300128
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发表时间：
2014-03-01
期刊：
影响因子：
4
通讯作者：
Luo, Lingfei
中科院分区：
文献类型：
--
作者：
Huang, Sizhou;Xu, Wenming;Luo, Lingfei
侧板中胚层（LPM）中的Nodal破坏通常会导致多个器官中的左右（LR）图案缺陷。然而，器官的LR模式是否总是以耦合的方式调节，在很大程度上尚未阐明。此外，在LPM中是否存在与Nodal协调调节器官LR模式的其他关键调节因子也未确定。在本文中，在简要总结了LR图案化的共同过程，最令人困惑的问题，关于启动的不对称性被认为是和不同的机制下的解耦LR图案在不同的器官进行了讨论。不同器官的LR模式的情况下，通过一个独立的机制或在不同的时间，以非耦合的方式确定的基础上，我们提出，有其他关键因素的LPM协调与Nodal调节心脏LR不对称模式在早期LR模式。
Disruption of Nodal in the lateral plate mesoderm (LPM) usually leads to left-right (LR) patterning defects in multiple organs. However, whether the LR patterning of organs is always regulated in a coupled way has largely not yet been elucidated. In addition, whether other crucial regulators exist in the LPM that coordinate with Nodal in regulating organ LR patterning is also undetermined. In this paper, after briefly summarizing the common process of LR patterning, the most puzzling question regarding the initiation of asymmetry is considered and the divergent mechanisms underlying the uncoupled LR patterning in different organs are discussed. On the basis of cases in which different organ LR patterning is determined in an uncoupled way via an independent mechanism or at a different time, we propose that there are other critical factors in the LPM that coordinate with Nodal to regulate heart LR asymmetry patterning during early LR patterning.