High Circulating Folate and Vitamin B-12 Concentrations in Women During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring
High Circulating Folate and Vitamin B-12 Concentrations in Women During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring
复制标题
DOI：
10.3945/jn.111.154948
复制
发表时间：
2012-04-01
影响因子：
4.2
通讯作者：
Moll, Henriette A.
中科院分区：
文献类型：
--
作者：
Kiefte-de Jong, Jessica C.;Timmermans, Sarah;Moll, Henriette A.
最近的研究表明，在子宫内暴露的甲基供体影响编程的胎儿免疫系统，有利于过敏性疾病的发展。本研究的目的是评估MTHFR C677 T多态性、叶酸补充、妊娠期循环叶酸和维生素B-12浓度是否与后代的喘息、呼吸短促和特应性皮炎相关。该研究是一项基于人群的出生队列研究，从胎儿期至48个月（n = 8742）。通过问卷调查评估妊娠期间叶酸补充剂的使用情况。血浆叶酸和血清维生素B-12浓度和MTHFR C677 T多态性可从妊娠早期采集的血液中获得。在12、24、36和48个月时，通过父母问卷调查评估后代的特应性皮炎、喘息和呼吸急促。母体叶酸>16.2 nmol/L和维生素B-12 >178 pmol/L与特应性皮炎的发生呈正相关[叶酸和维生素B-12浓度最高四分位数的校正OR分别为0.18（95%CI：1.05-1.33）和1.30（95%CI：1.06-1.60）]，但与喘息和呼吸短促无关。母亲MTHFR C677 T多态性和叶酸补充与喘息、呼吸短促和特应性皮炎无关。未发现年龄、特应性家族史、叶酸补充、MTHFR C677 T多态性或母亲吸烟的相互作用（P-相互作用> 0.10）。怀孕期间叶酸和维生素B-12水平高与后代特应性皮炎患病率增加有关。在讨论强制性强化计划时，应评估高叶酸和维生素8-12浓度对过敏结果的潜在风险。J.营养142：731-738，2012年。
Recent studies suggest that in utero exposure of methyl donors influences programming of the fetal immune system in favor of development of allergic disease. The aim of this study was to assess whether the MTHFR C677T polymorphism, folic acid supplementation, and circulating folate and vitamin B-12 concentrations during pregnancy were associated with wheezing, shortness of breath, and atopic dermatitis in offspring. The study was a population-based birth cohort from fetal life until 48 mo (n = 8742). The use of folic acid supplementation during pregnancy was assessed by questionnaire. Plasma folate and serum vitamin B-12 concentrations and the MTHFR C677T polymorphism were available from blood collected in early pregnancy. Atopic dermatitis, wheezing, and shortness of breath in the offspring were assessed by parental-derived questionnaires at 12, 24, 36, and 48 mo. Maternal folate >16.2 nmol/L and vitamin B-12 >178 pmol/L were positively associated with the development of atopic dermatitis [adjusted OR:.1.18 (95%CI: 1.05-1.33) and adjusted OR: 1.30 (95% Cl: 1.06-1.60) for the highest quartiles of folate and vitamin B-12 concentrations, respectively) but not with wheezing and shortness of breath. Maternal MTHFR C677T polymorphism and folic acid supplementation were not associated with wheezing, shortness of breath, and atopic dermatitis. No interactions were found by age, family history of atopy, folic acid supplementation, MTHFR C677T polymorphism, or maternal smoking (P-interaction > 0.10). High folate and vitamin B-12 levels during pregnancy are associated with increased prevalence of atopic dermatitis in the offspring. Potential risks of high folate and vitamin 8-12 concentrations on allergic outcomes should be evaluated when discussing mandatory fortification programs. J. Nutr. 142: 731-738, 2012.