Impaired lung function is associated with obesity and metabolic syndrome in adults
Impaired lung function is associated with obesity and metabolic syndrome in adults
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DOI：
10.1038/oby.2006.190
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发表时间：
2006-09-01
期刊：
影响因子：
6.9
通讯作者：
Huang, Kuo-Chin
中科院分区：
文献类型：
--
作者：
Lin, Wen-Yuan;Yao, Chien-An;Huang, Kuo-Chin
目的：肺功能受损。与肥胖和胰岛素抵抗有关。在这项研究中，我们调查了成人代谢综合征与肺功能受损之间的关系。 研究方法和程序：自 1998 年至 2017 年，从台湾四个全国性 MJ 健康检查中心招募了总共 46,514 名 20 岁及以上受试者（21,669 名男性和 24,845 名女性，平均年龄分别为 37.3 +/- 11.2 和 37.0 +/- 11.3 岁）。 2000 年。代谢综合征是使用国家胆固醇教育小组 (NCEP) 代谢综合征标准或美国心脏协会/国家心肺血液研究所 (AHA/NHLBI) 标准定义的。采用多变量逻辑回归分析来检验代谢综合征与肺功能测试之间的关系。结果：男性肺功能受损的患病率为11.1%，女性为14.0%。根据 NCEP 标准，代谢综合征的患病率为 5.8%；根据 AHA/NHLBI 标准，代谢综合征的患病率为 12.8%。在调整年龄、性别、BMI、吸烟、饮酒和体力活动的多变量逻辑回归分析中，限制性肺损伤与代谢综合征风险增加独立相关（p < 0.01，比值比 = 1.221（使用 NCEP 标准）和 1.150（使用 AHA/NHLBI 标准）。讨论：肥胖和代谢综合征与台湾成人肺功能受损相关。我们的结果表明肥胖和胰岛素抵抗可能是肺功能损伤和代谢综合征的常见途径。此外，肺功能测试可作为临床环境中代谢综合征的附加评估。
Objective: Impaired lung function. is associated with obesity and insulin resistance. In this study, we investigated the relationship between metabolic syndrome and impaired lung function in adults.Research Methods and Procedures: A total of 46,514 subjects 20 years and over (21,669 men and 24,845 women, mean age = 37.3 +/- 11.2 and 37.0 +/- 11.3 years, respectively) were recruited from four nationwide MJ Health Screening Centers in Taiwan from 1998 to 2000. Metabolic syndrome was defined using the National Cholesterol Education Panel (NCEP) metabolic syndrome criteria or America Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) criteria. The relationship between metabolic syndrome and lung function test was examined using multivariate logistic regression analysis.Results: The prevalence of impaired lung function was 11.1% in men and 14.0% in women. The prevalence of metabolic syndrome was 5.8% using NCEP criteria and 12.8% using AHA/NHLBI criteria. In multivariate logistic regression analysis with adjustment for age, gender, BMI, smoking, alcohol drinking, and physical activity, restrictive lung impairment was independently associated with increased risk of having metabolic syndrome (p < 0.01, odds ratios = 1.221 using NCEP criteria and 1.150 using AHA/NHLBI criteria).Discussion: Obesity and metabolic syndrome were associated with impaired lung function in adults in Taiwan. Our results imply that obesity and insulin resistance may be the common pathways underlying lung function impairment and metabolic syndrome. Moreover, lung function test may be applied as an additional evaluation for metabolic syndrome in a clinical setting.