Long-term outcome and prognostic factors of intrahepatic cholangiocarcinoma
Long-term outcome and prognostic factors of intrahepatic cholangiocarcinoma
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DOI：
10.3760/cma.j.issn.0366-6999.2009.19.018
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发表时间：
2009-10-05
影响因子：
6.1
通讯作者：
Chen Dong
中科院分区：
文献类型：
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作者：
Li Shao-qiang;Liang Li-jian;Chen Dong
背景由于预后差，肝内胆管细胞癌(ICC)的治疗仍然是一个挑战。本研究旨在总结近10年来单中心肝胆中心胆管内胆管结石患者的手术治疗经验，探讨影响其预后的相关因素。方法对1995年1月至2005年6月收治的136例肝内胆管中心癌患者的临床资料进行回顾性分析。采用Kaplan-Meier方法计算患者的生存率，采用对数等级检验进行比较。结果136例患者中行手术切除79例，治愈(RO)65例。手术死亡率为2.2%。根治性切除组1、3、5年生存率分别为72.1%、35.6%和20.1%，明显高于姑息性切除组和探查组(P
Background The management of intrahepatic cholangiocarcinoma (ICC) remains a challenge due to poor prognosis. The aim of this study was to summarize the surgical management experience in recent 10 years and to identify the influencing factors related to outcome of patients with ICC in a single hepatobiliary center.Methods From January 1995 to June 2005, 136 patients with ICC undergoing surgery were reviewed retrospectively. Survival rates of patients were calculated using the Kaplan-Meier method and compared by using the log-rank test. The prognostic factors were identified by the Cox regression model.Results Seventy-nine of 136 patients underwent resection, and 65 of 79 patients were curative (RO). The surgical mortality was 2.2%. The 1-, 3- and 5-year survival rates of patients undergoing RO resection were 72.1%, 35.6% and 20.1% respectively, which were significantly longer than those who underwent palliative resection and exploration, respectively (P