Antioxidant vitamins and lipid peroxidation in patients with cervical intraepithelial neoplasia
Antioxidant vitamins and lipid peroxidation in patients with cervical intraepithelial neoplasia
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DOI：
10.3346/jkms.2005.20.2.267
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发表时间：
2005-04-01
影响因子：
4.5
通讯作者：
Ahn, HS
中科院分区：
文献类型：
--
作者：
Lee, GJ;Chung, HW;Ahn, HS
本研究的目的是探讨饮食摄入和血浆抗氧化剂，脂质过氧化反应，抗氧化能力在韩国妇女宫颈上皮内瘤变（CIN）的水平的影响。从2002年10月至2003年3月，58例诊断为CIN的患者（经阴道镜直接活检证实）和86例无任何宫颈疾病的患者作为对照组参加了三星第一医院妇科癌症中心的研究。两组的抗氧化维生素摄入量都超过了韩国RDA第7版推荐的量。维生素C的血浆浓度在CIN组（0.36 mg/dL）中显著低于对照组（0.48 mg/dL）（p < 0.05）。两组显示出相似的R-胡萝卜素、α-生育酚和视黄醇的血浆浓度。CIN组的丙二醛平均浓度为7.23 mmol/mL，显著高于对照组的5.18 mmol/mL（p < 0.01）。CIN组血浆中总自由基捕获抗氧化潜力浓度（1.15 mM）显著高于对照组（1.25 mM）（p < 0.05）。这些结果表明，宫颈上皮内瘤变过程和血浆抗氧化系统的变化之间可能存在相关性。
The purpose of this study was to investigate the implications of dietary intake and the level of plasma antioxidant, lipid peroxidation, and antioxidant capacity in Korean women with cervical intraepithelial neoplasia (CIN). From October 2002 to March 2003, 58 patients diagnosed with CIN (confirmed with colposcopy directed biopsy) and 86 patients without any cervical disease as control group were enrolled in the study at the Department of Gynecology cancer center at Samsung Cheil Hospital. The intake of antioxidant vitamins in both groups exceeded the amount recommended by the Korea RDA, 7th edition. The plasma concentration of Vitamin C was significantly lower in the CIN group (0.36 mg/dL) than in the control group (0.48 mg/dL) (p < 0.05). The two groups showed similar plasma concentrations of R-carotene, a-tocopherol, and retinol. The average concentration of malondialdehydes in the CIN group, 7.23 mmol/mL, was significantly higher than in the control group, 5.18 mmol/mL (p < 0.01). The total radical trapping antioxidant potential concentration of plasma was significantly higher in the CIN group (1.15 mM) than in the control group (1.25 mM) (p < 0.05). These results suggest that there is a possible correlation between cervical intraepithelial neoplastic processes and changes in the plasma antioxidative system.