Intramedullary spinal cord metastases in breast cancer are associated with improved longer-term systemic control.
Intramedullary spinal cord metastases in breast cancer are associated with improved longer-term systemic control.
复制标题
乳腺癌髓内脊髓转移与长期全身控制的改善相关。
DOI：
10.2217/fon.10.118
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发表时间：
2010
期刊：
影响因子：
3.3
通讯作者：
J. Krell
中科院分区：
文献类型：
--
作者：
A. Zebrowski;L. Wilson;A. Lim;J. Stebbing;J. Krell
脊髓髓内转移是一种罕见的恶性肿瘤并发症，预后不良。我们描述了三例经过广泛治疗的晚期乳腺癌患者发生髓内转移，其中两例接受曲妥珠单抗治疗，其中一例为男性。随着治疗的进步提高了转移性乳腺癌患者的总体存活率，疾病的模式正在随着系统控制的改善而改变。脊髓髓内转移的发生率可能会增加，但治疗策略仍不清楚。
Intramedullary spinal cord metastases are a rare complication of malignancy, associated with a poor prognosis. We describe three cases with extensively pretreated advanced breast cancer developing intramedullary spinal cord metastases two of whom were receiving trastuzumab, one of whom was a male. As therapeutic advances increase overall survival for patients with metastatic breast cancer, patterns of disease are changing with improved systemic control. The incidence of intramedullary spinal cord metastases is likely to increase but management strategies remain unclear.