Free radical oxidation of (E)-retinoic acid by prostaglandin H synthase.
Free radical oxidation of (E)-retinoic acid by prostaglandin H synthase.
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前列腺素 H 合酶对 (E)-视黄酸进行自由基氧化。
DOI：
10.1021/tx00047a022
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发表时间：
1995
影响因子：
4.1
通讯作者：
Lloyd,RV
中科院分区：
文献类型：
--
作者：
Samokyszyn,VM;Chen,T;Maddipati,KR;Franz,TJ;Lehman,PA;Lloyd,RV
3.2 G = 15.8 G。反应混合物的反相HPLC分析表明形成了4-羟基-RA、5，6-环氧-RA、4-氧代-RA、（13 Z）-视黄酸和其它几何异构体，其基于与合成标准品的共色谱法、UV光谱法和/或质谱法鉴定。机制提出的过氧化氢依赖性，PGH β-catalyzed氧化RA是与这些结果相一致。
3.2 G and on= 15.8 G. Reverse phase HPLC analysis of reaction mixtures demonstrated the formation of 4-hydroxy-RA, 5, 6-epoxy-RA, 4-oxo-RA,(13Z)-retinoic acid, and other geometric isomers which were identified on the basis of cochromatography with synthetic standards, UV spectroscopy, and/or mass spectrometry. Mechanisms are proposed for the hydroperoxide-dependent, PGH synthasecatalyzed oxidation of RA that are consistent with these results.