Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
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DOI：
10.1161/01.cir.101.24.2863
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发表时间：
2000-06-20
期刊：
影响因子：
37.8
通讯作者：
Weiss, RM
中科院分区：
文献类型：
--
作者：
Hill, JA;Karimi, M;Weiss, RM
背景-心脏肥大被认为是一个必要的代偿反应，持续升高的左心室（LV）壁stress.Methods和结果-为了测试这一点，我们抑制钙调神经磷酸酶与环孢素（CsA）在设置手术诱导的压力超负荷小鼠和检查在体内参数的心室容积和功能超声心动图。胸主动脉结扎后5周，标准化心脏重量增加45%（TAB;心脏重量/体重，8.3 ± 0.9 mg/g [平均值+/-SE] vs 5.7 ± 0.1 mg/g未结扎，P
Background-Cardiac hypertrophy is considered a necessary compensatory response to sustained elevations of left ventricular (LV) wall stress.Methods and Results-To test this, we inhibited calcineurin with cyclosporine (CsA) in the setting of surgically induced pressure overload in mice and examined in vivo parameters of ventricular volume and function using echocardiography. Normalized heart mass increased 45% by 5 weeks after thoracic aortic banding (TAB; heart weight/body weight, 8.3+/-0.9 mg/g [mean+/-SE] versus 5.7+/-0.1 mg/g unbanded, P