Survival of the simplest in microbial evolution
Survival of the simplest in microbial evolution
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DOI：
10.1038/s41467-019-10413-8
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发表时间：
2019-06-06
影响因子：
16.6
通讯作者：
Laessig, Michael
中科院分区：
文献类型：
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作者：
Held, Torsten;Klemmer, Daniel;Laessig, Michael
微生物和病毒生物的进化经常产生克隆干扰，这是种群内遗传进化枝之间的竞争模式。在这里，我们展示了干扰如何通过限制遗传和表型复杂性来影响系统生物学。我们的分析使用基于生物物理的分子表型进化模型，如基因的折叠稳定性和酶活性。我们发现了一种表型干扰的通用模式，这种模式将个体基因的功能和种群的全球进化动态耦合在一起。表型干扰的生物学意义包括适应实验中的快速侧系退化和针对基因组复杂性的长期选择：每个额外基因的成本与基因总数成正比。高于阈值的重组率可以消除这种成本，从而为性别进化建立了一个普遍的、基于生物物理的情景。在更广泛的背景下，我们的分析表明，微生物的系统生物学与它们的进化模式密切相关。
The evolution of microbial and viral organisms often generates clonal interference, a mode of competition between genetic clades within a population. Here we show how interference impacts systems biology by constraining genetic and phenotypic complexity. Our analysis uses biophysically grounded evolutionary models for molecular phenotypes, such as fold stability and enzymatic activity of genes. We find a generic mode of phenotypic interference that couples the function of individual genes and the population's global evolutionary dynamics. Biological implications of phenotypic interference include rapid collateral system degradation in adaptation experiments and long-term selection against genome complexity: each additional gene carries a cost proportional to the total number of genes. Recombination above a threshold rate can eliminate this cost, which establishes a universal, biophysically grounded scenario for the evolution of sex. In a broader context, our analysis suggests that the systems biology of microbes is strongly intertwined with their mode of evolution.