Development of a Stretchable and Water-Resistant Hydrogel with Antibacterial and Antioxidant Dual Functions for Wound Healing in Movable Parts
Development of a Stretchable and Water-Resistant Hydrogel with Antibacterial and Antioxidant Dual Functions for Wound Healing in Movable Parts
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DOI：
10.1021/acsami.3c08782
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发表时间：
2023-09-11
影响因子：
9.5
通讯作者：
Wang，Jian
中科院分区：
文献类型：
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作者：
Zhang，Shu;Yang，Linxin;Wang，Jian
由于机械匹配不良以及持续运动和炎症引起的二次损伤，身体运动部位（例如关节）上出现的伤口的治疗被认为是一项挑战。本文中，开发了一种可拉伸的多功能水凝胶敷料，其利用壳聚糖（CS）和丙烯酸（AA）的双重交联并用咖啡酸（CA）和芦荟苷（Alo）改性。机械测试表明，水凝胶具有优异的拉伸能力（约869%），结合出色的粘附力（约56 kPa），有助于其与活动部件的相容性，并允许完全覆盖伤口部位，而不限制关节和器官运动。生物信息学分析证实，水凝胶的使用导致与血管生成和细胞增殖相关的多个基因的表达上调。此外，抗菌测试表明，敷料抑制大肠杆菌和耐甲氧西林金黄色葡萄球菌（MRSA）的生长，为伤口愈合提供了更好的微环境。可移动皮肤上的Anin vivowound缺损模型证实，使用水凝胶敷料观察到的伤口愈合上级使用市售敷料观察到的伤口愈合。综上所述，结果表明，可拉伸多功能水凝胶敷料代表了一种有前景的替代伤口敷料，具有上级愈合的治疗潜力，尤其是对于身体的活动部位。
The treatment of wounds that develop on moving parts of the body, such as joints, is considered a challenge due to poor mechanical matching and secondary injury caused by continuous motion and inflammation. Herein, a stretchable, multifunctional hydrogel dressing utilizing the dual cross-linking of chitosan (CS) and acrylic acid (AA) and modified with caffeic acid (CA) and aloin (Alo) was developed. Mechanical testing demonstrated that the hydrogel possessed excellent stretching capability (of approximately 869%) combined with outstanding adhesion (about 56 kPa), contributing to its compatibility with moving parts and allowing complete coverage of wound sites without limiting joint and organ motion. Bioinformatics analysis confirmed that use of the hydrogel resulted in upregulated expression of multiple genes related to angiogenesis and cell proliferation. Furthermore, antibacterial testing indicated that the dressing suppressed the growth ofEscherichia coliand methicillin-resistantStaphylococcus aureus(MRSA), providing a better microenvironment for wound healing. Anin vivowound defect model on movable skin verified that the wound healing observed with the hydrogel dressing was superior to that observed with a commercially available dressing. Taken together, the results suggest that a stretchable multifunctional hydrogel dressing represents a promising alternative wound dressing with therapeutic potential for superior healing, especially for moving parts of the body.