Direct Catalytic Synthesis of Unprotected 2-Amino-1-Phenylethanols from Alkenes by Using Iron(II) Phthalocyanine
Direct Catalytic Synthesis of Unprotected 2-Amino-1-Phenylethanols from Alkenes by Using Iron(II) Phthalocyanine
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DOI：
10.1002/anie.201507630
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发表时间：
2016-02-05
影响因子：
16.6
通讯作者：
Morandi, Bill
中科院分区：
文献类型：
--
作者：
Legnani, Luca;Morandi, Bill
芳基取代氨基醇是药物化学和天然产物中的重要支架材料。在此，我们报道了一种非常简单和廉价的Fe-II络合物以良好的产率和良好的区域选择性有效地催化简单的烯烃直接转化为无保护的氨基醇。这种新的催化方法被应用于生物活性分子的简便合成，并可推广到氨基醚化反应中。
Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products. Herein, we report that an exceptionally simple and inexpensive Fe-II complex efficiently catalyzes the direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity. This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.