The Correlation Between Bubble-Enhanced HIFU Heating and Cavitation Power
The Correlation Between Bubble-Enhanced HIFU Heating and Cavitation Power
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DOI：
10.1109/tbme.2009.2028133
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发表时间：
2010-01-01
影响因子：
4.6
通讯作者：
Roy, Ronald A.
中科院分区：
文献类型：
--
作者：
Farny, Caleb H.;Holt, R. Glynn;Roy, Ronald A.
已经确定的是，虽然固有存在的气泡由于散射和吸收而增加热生成，但是惯性空化是高强度聚焦超声（HIFU）应用期间升高的加热的原因。气泡引起的加热的贡献可以是要考虑的重要因素，因为它可以比来自初级超声场的能量吸收的预期热沉积大几倍。在仿组织模型中，测量了5.5 s连续波1.1 MHz HIFU声处理的焦点附近的温度和空化信号。测量的温度被校正为从初级超声吸收预测的加热，以将温度升高与气泡活动隔离。由空化引起的温度升高与瞬时“空化功率”的测量值相关良好，如由15 MHz被动空化检测器的均方电压输出所示。结果表明，仔细处理的空化信号可以作为测量惯性空化的加热贡献的代理。
It has been established that while the inherent presence of bubbles increases heat generation due to scattering and absorption, inertial cavitation is responsible for elevated heating during high-intensity focused ultrasound (HIFU) application. The contribution of bubble-induced heating can be an important factor to consider, as it can be several times greater than the expected heat deposition from absorption of energy from the primary ultrasound field. The temperature and cavitation signal near the focus were measured for 5.5-s continuous-wave 1.1-MHz HIFU sonications in tissue mimicking phantoms. The measured temperature was corrected for heating predicted from the primary ultrasound absorption to isolate the temperature rise from the bubble activity. The temperature rise induced from cavitation correlates well with a measurement of the instantaneous "cavitation power" as indicated by the mean square voltage output of a 15-MHz passive cavitation detector. The results suggest that careful processing of the cavitation signals can serve as a proxy for measuring the heating contribution from inertial cavitation.