Ruthenium-catalyzed [2 + 2] cycloaddition of allenynes leading to a bicyclo[4.2.0]octa-1(8),5-diene skeleton.
Ruthenium-catalyzed [2 + 2] cycloaddition of allenynes leading to a bicyclo[4.2.0]octa-1(8),5-diene skeleton.
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DOI：
10.1021/ol901616b
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发表时间：
2009-08
期刊：
影响因子：
5.2
通讯作者：
Nozomi Saito;Yuki Tanaka;Y. Sato
中科院分区：
文献类型：
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作者：
Nozomi Saito;Yuki Tanaka;Y. Sato
Cp*RuCl（cod）催化的联烯炔环化反应的反应途径根据所用溶剂的类型而显著改变。也就是说，当丙二炔在甲苯中进行环二聚得到五环化合物时，双环[4.2.0]辛-1（8），5-二烯衍生物仅通过丙二炔在甲醇中的[2 + 2]环加成产生。研究还表明，Cp*RuCl（cod）与甲醇原位生成的阳离子钌配合物可催化[2 + 2]环加成反应.
The reaction pathway of Cp*RuCl(cod)-catalyzed cyclization of allenynes was dramatically changed depending on the type of solvent employed. That is, while a cyclodimerization of allenyne proceeded to give a pentacyclic compound in toluene, a bicyclo[4.2.0]octa-1(8),5-diene derivative was exclusively produced by [2 + 2] cycloaddition of allenyne in methanol. It was also demonstrated that the [2 + 2] cycloaddition was catalyzed by a cationic ruthenium complex generated from Cp*RuCl(cod) and methanol in situ.