Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States.
Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States.
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DOI：
10.1001/jama.2008.892
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发表时间：
2008-12-24
影响因子：
120.7
通讯作者：
Lindau, Stacy Tessler
中科院分区：
文献类型：
--
作者：
Qato, Dima M.;Alexander, G. Caleb;Conti, Rena M.;Johnson, Michael;Schumm, Phil;Lindau, Stacy Tessler
尽管人们担心药物安全，但目前有关老年人使用处方药、非处方药和膳食补充剂的信息仍然有限。估计老年人用药的流行率和模式（包括同时使用），以及潜在的主要药物相互作用。从美国具有全国代表性的横截面概率样本中抽取了 3005 名年龄在 57 岁至 85 岁之间的社区居民。 2005 年 6 月至 2006 年 3 月期间进行了家庭访谈，包括用药记录。药物使用被定义为“定期（例如每天或每周）”使用处方药、非处方药和膳食补充剂。并发使用定义为定期使用至少 2 种药物。按年龄组和性别分层的药物使用流行率、同时使用和潜在的主要药物相互作用的人群估计。未加权调查回复率为 74.8%（加权调查回复率为 75.5%）。 81%（95% 置信区间 [CI]，79.4%–83.5%）使用至少 1 种处方药，42%（95% CI，39.7%–44.8%）使用至少 1 种非处方药，49%（95% CI，46.2%–52.7%）使用膳食补充剂。 29%（95% CI，26.6%–30.6%）同时使用至少 5 种处方药； 75 至 85 岁的男性（37.1%；95% CI，31.7%–42.4%）和女性（36.0%；95% CI，30.2%–41.9%）中这一比例最高。在处方药使用者中，同时使用非处方药的比例为 46%（95% CI，43.4%–49.1%），同时使用膳食补充剂的比例为 52%（95% CI，48.8%–55.5%）。总体而言，4% 的人存在发生重大药物相互作用的潜在风险；其中一半涉及使用非处方药。这些治疗方案在年龄最大的男性中最为普遍（10%；95% CI，6.4%–13.7%），并且近一半涉及抗凝药物。未发现同时使用药物的禁忌症。在这个社区老年人样本中，处方药和非处方药通常一起使用，近二十五人中就有一人面临重大药物相互作用的风险。
Despite concerns about drug safety, current information on older adults’ use of prescription and over-the-counter medications and dietary supplements is limited. To estimate the prevalence and patterns of medication use among older adults (including concurrent use), and potential major drug-drug interactions. Three thousand five community-residing individuals, aged 57 through 85 years, were drawn from a cross-sectional, nationally representative probability sample of the United States. In-home interviews, including medication logs, were administered between June 2005 and March 2006. Medication use was defined as prescription, over-the-counter, and dietary supplements used “on a regular schedule, like every day or every week.” Concurrent use was defined as the regular use of at least 2 medications. Population estimates of the prevalence of medication use, concurrent use, and potential major drug-drug interactions, stratified by age group and gender. The unweighted survey response rate was 74.8% (weighted response rate, 75.5%). Eighty-one percent (95% confidence interval [CI], 79.4%–83.5%) used at least 1 prescription medication, 42% (95% CI, 39.7%–44.8%) used at least 1 over-the-counter medication, and 49% (95% CI, 46.2%–52.7%) used a dietary supplement. Twenty-nine percent (95% CI, 26.6%–30.6%) used at least 5 prescription medications concurrently; this was highest among men (37.1%; 95% CI, 31.7%–42.4%) and women (36.0%; 95% CI, 30.2%–41.9%) aged 75 to 85 years. Among prescription medication users, concurrent use of over-the-counter medications was 46% (95% CI, 43.4%–49.1%) and concurrent use of dietary supplements was 52% (95% CI, 48.8%–55.5%). Overall, 4% of individuals were potentially at risk of having a major drug-drug interaction; half of these involved the use of nonprescription medications. These regimens were most prevalent among men in the oldest age group (10%; 95% CI, 6.4%–13.7%) and nearly half involved anticoagulants. No contraindicated concurrent drug use was identified. In this sample of community-dwelling older adults, prescription and nonprescription medications were commonly used together, with nearly 1 in 25 individuals potentially at risk for a major drug-drug interaction.
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影响因子：
120.7
作者：
Curtis, Lesley H.;Al-Khatib, Sana M.;Schulman, Kevin A.
通讯作者：
Schulman, Kevin A.
影响因子：
9.7
作者：
Catlin, Aaron;Cowan, Cathy;Heffler, Stephen
通讯作者：
Heffler, Stephen
影响因子：
39.2
作者：
Saaddine, JB;Cadwell, B;Narayan, KMV
通讯作者：
Narayan, KMV
影响因子：
12.7
作者：
FILLENBAUM, GG;HANLON, JT;BROCK, D
通讯作者：
BROCK, D
影响因子：
2.9
作者：
Elmer, Gary W.;Lafferty, William E.;Lind, Bonnie K.
通讯作者：
Lind, Bonnie K.