Palladium-catalyzed synthesis of indoles via ammonia cross-coupling-alkyne cyclization
Palladium-catalyzed synthesis of indoles via ammonia cross-coupling-alkyne cyclization
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DOI：
10.1039/c1cc11874a
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Stradiotto, Mark
中科院分区：
文献类型：
--
作者：
Alsabeh, Pamela G.;Lundgren, Rylan J.;Stradiotto, Mark
首次报道了通过氨的金属催化交叉偶联合成吲哚;开发的协议还允许前所未有地使用甲胺或肼作为偶联伙伴。这些Pd/Josivaline催化的反应在相对温和的条件下进行的范围内的2-炔基溴芳烃。
The synthesis of indoles via the metal-catalyzed cross-coupling of ammonia is reported for the first time; the developed protocol also allows for the unprecedented use of methylamine or hydrazine as coupling partners. These Pd/Josiphos-catalyzed reactions proceed under relatively mild conditions for a range of 2-alkynylbromoarenes.