Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review
Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review
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涉及胎盘母腔的 21 三体性相关短暂性骨髓细胞生成异常：一例报告及文献综述
DOI：
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发表时间：
2014
影响因子：
1.9
通讯作者：
O. Faye
中科院分区：
文献类型：
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作者：
Q. Dai;Vishnu V. B. Reddy;J. Choi;O. Faye
我们报告一例21三体综合征的男性新生儿和出生时的短暂异常骨髓细胞生成，其胎盘显示外渗的胎儿原始细胞在绒毛周围（母亲）的空间。对胎儿恶性肿瘤可能的母体扩散的担忧促使在产后第2天对母体外周血进行Kleihauer-Betke试验和流式细胞术分析。值得注意的是，未发现母体血液中胎儿细胞持续存在的证据，这一发现可能反映了胎儿原始细胞和红细胞的成功母体免疫清除，和/或原始细胞脆性和有限的活力。据我们所知，我们的报告是第一个在英文文献中记录这种疾病的母亲外周血随访评估的报告。我们讨论我们的情况下，胎儿新生儿实体瘤和白血病增殖性疾病与胎盘参与和母体转移的证据进行了全面审查。
We report a case of a male newborn with trisomy 21 and transient abnormal myelopoiesis at birth whose placenta showed extravasated fetal blasts in the perivillous (maternal) space. Concern for possible maternal spread of fetal malignancy prompted a Kleihauer-Betke test and flow cytometric analysis of the maternal peripheral blood on postpartum day 2. Notably, no evidence of the persistence of fetal cells in the maternal blood was identified, a finding that likely reflected successful maternal immunologic clearance of the fetal blasts and erythrocytes, and/or blast cellular fragility and limited viability. Ours is the first report, to our knowledge, documenting maternal peripheral-blood follow-up evaluation of this disorder in the English literature. We discuss our case in the context of a comprehensive review of fetoneonatal solid tumor and leukemic proliferative disorders with placental involvement and evidence of maternal metastasis.