Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication
Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication
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DOI：
10.1038/s41440-021-00679-1
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发表时间：
2021-06-11
影响因子：
5.4
通讯作者：
Miura, Tetsuji
中科院分区：
文献类型：
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作者：
Furuhashi, Masato;Higashiura, Yukimura;Miura, Tetsuji
黄嘌呤氧化还原酶（Xanthine oxidoreductase，XOR）是嘌呤代谢中尿酸形成的限速酶和催化酶，参与活性氧的产生。血浆XOR活性已被证明是与肥胖、肝功能障碍、高尿酸血症、血脂异常和胰岛素抵抗相关的新型代谢生物标志物。然而，血浆XOR活性与高血压之间的关系尚未完全阐明。我们在Tanno-Sobetsu研究（一个基于人群的队列）中调查了271名未服用任何药物的非糖尿病受试者（男性/女性：119/152）的高血压与血浆XOR活性的关系。男性血浆XOR活性高于女性。血浆XOR活性与平均动脉压呈正相关（r = 0.128，P = 0.036）。当受试者按有无高血压分为HT组（男/女：34/40）和非HT组（男/女：85/112）时，HT组的血浆XOR活性显著高于非HT组（中位数：39 vs. 28 pmol/h/mL，P = 0.028）。两组间尿酸水平无显著差异。多因素Logistic回归分析显示，血浆XOR活性（比值比：1.091 [95%置信区间：1.023-1.177]/10 pmol/h/mL，P = 0.007）是调整年龄、性别、当前吸烟和饮酒、估计肾小球滤过率、脑钠肽、和胰岛素抵抗指数。性别与血浆XOR活性的交互作用对高血压的危险性无显著影响。总之，血浆XOR活性与未服用任何药物的非糖尿病个体的高血压独立相关。
Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR activity has been shown to be a novel metabolic biomarker related to obesity, liver dysfunction, hyperuricemia, dyslipidemia, and insulin resistance. However, the association between plasma XOR activity and hypertension has not been fully elucidated. We investigated the association of hypertension with plasma XOR activity in 271 nondiabetic subjects (male/female: 119/152) who had not taken any medications in the Tanno-Sobetsu Study, a population-based cohort. Males had higher plasma XOR activity than females. Plasma XOR activity was positively correlated with mean arterial pressure (r = 0.128, P = 0.036). When the subjects were divided by the presence and absence of hypertension into an HT group (male/female: 34/40) and a non-HT group (male/female: 85/112), plasma XOR activity in the HT group was significantly higher than that in the non-HT group (median: 39 vs. 28 pmol/h/mL, P = 0.028). There was no significant difference in uric acid levels between the two groups. Multivariable logistic regression analysis showed that plasma XOR activity (odds ratio: 1.091 [95% confidence interval: 1.023-1.177] per 10 pmol/h/mL, P = 0.007) was an independent determinant of the risk for hypertension after adjustment for age, sex, current smoking and alcohol consumption, estimated glomerular filtration rate, brain natriuretic peptide, and insulin resistance index. The interaction of sex with plasma XOR activity was not significant for the risk of hypertension. In conclusion, plasma XOR activity is independently associated with hypertension in nondiabetic individuals who are not taking any medications.