Peripheral insulin administration enhances the electrical activity of oxytocin and vasopressin neurones in vivo.
Peripheral insulin administration enhances the electrical activity of oxytocin and vasopressin neurones in vivo.
复制标题
外周胰岛素给药增强体内催产素和加压素神经元的电活动。
DOI：
10.1111/jne.12841
复制
发表时间：
2020
影响因子：
3.2
通讯作者：
Paiva L
中科院分区：
文献类型：
--
作者：
Paiva L
催产素神经元通过不同的中枢和外周作用参与能量平衡的调节，在大鼠中，它们通过强饲甜味物质而被有效激活。在这里，我们测试的假设，这种激活是由胰岛素的中枢作用介导的。我们发现，在乌拉坦麻醉的大鼠中，静脉注射胰岛素后，视上核中的催产素细胞显示出延长的激活，并且禁食大鼠的这种反应比非禁食大鼠更大。加压素细胞也被激活，尽管不那么一致。我们还表明，催产素细胞的这种激活是独立的血浆葡萄糖浓度的变化，并完全被中央（i.c.v.）胰岛素受体拮抗剂的施用。最后，我们复制了先前发表的发现，催产素细胞被激活的甜炼乳管饲，并表明，这种反应也被完全阻断了胰岛素受体拮抗剂的中央管理。我们的结论是催产素细胞的反应，灌胃甜炼乳介导的胰岛素的中枢作用。
Oxytocin neurones are involved in the regulation of energy balance through diverse central and peripheral actions and, in rats, they are potently activated by gavage of sweet substances. Here, we test the hypothesis that this activation is mediated by the central actions of insulin. We show that, in urethane‐anaesthetised rats, oxytocin cells in the supraoptic nucleus show prolonged activation after i.v. injections of insulin, and that this response is greater in fasted rats than in non‐fasted rats. Vasopressin cells are also activated, although less consistently. We also show that this activation of oxytocin cells is independent of changes in plasma glucose concentration, and is completely blocked by central (i.c.v.) administration of an insulin receptor antagonist. Finally, we replicate the previously published finding that oxytocin cells are activated by gavage of sweetened condensed milk, and show that this response too is completely blocked by central administration of an insulin receptor antagonist. We conclude that the response of oxytocin cells to gavage of sweetened condensed milk is mediated by the central actions of insulin.