Hidden randomness between fitness landscapes limits reverse evolution.
Hidden randomness between fitness landscapes limits reverse evolution.
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适应度景观之间隐藏的随机性限制了逆向进化。
DOI：
10.1103/physrevlett.106.198102
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发表时间：
2011
影响因子：
8.6
通讯作者：
Gore,Jeff
中科院分区：
文献类型：
--
作者：
Tan,Longzhi;Serene,Stephen;Chao,HuiXiao;Gore,Jeff
在生物进化中，对一种环境的适应在某些情况下可以逆转对另一种环境的适应。为了在基因型水平上研究这种“反向进化”，我们在两种不同的抗生素环境中测量了大肠杆菌菌株与一个耐药基因中五个突变的每种可能组合的适应性。虽然对一种环境的适应通常会降低另一种环境的适应性，但我们发现逆向进化很少可能，并且随着适应复杂性的增加而福尔斯，这表明了多洛定律的概率分子形式。
In biological evolution, adaptations to one environment can in some cases reverse adaptations to another environment. To study this “reverse evolution” on a genotypic level, we measured the fitness ofE. colistrains with each possible combination of five mutations in an antibiotic-resistance gene in two distinct antibiotic environments. While adaptations to one environment generally lower fitness in the other, we find that reverse evolution is rarely possible and falls as the complexity of adaptations increases, suggesting a probabilistic, molecular form of Dollo’s law.