Effects of hippocampus and medial caudate nucleus lesions on memory for direction information in rats
Effects of hippocampus and medial caudate nucleus lesions on memory for direction information in rats
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DOI：
10.1037/0735-7044.118.3.540
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发表时间：
2004-06-01
影响因子：
1.9
通讯作者：
Kesner, RP
中科院分区：
文献类型：
--
作者：
DeCoteau, WE;Hoang, L;Kesner, RP
一项延迟的样本匹配任务被设计来评估大鼠对方向信息的记忆。在研究阶段，大鼠以三个方向中的一个方向穿越迷宫手臂。在一段延迟期之后，出现了需要在研究阶段方向和箔片方向之间进行选择的测试阶段。一旦大鼠达到学习标准，探测试验表明，正常大鼠倾向于使用方向，而不是转向反应、信息和使用前庭反馈。然后给予大鼠海马区、内侧尾状核(MCN)或皮质对照损毁。与对照组大鼠不同，那些有海马体和MCN损伤的大鼠在重新测试时表现出明显的损害。然而，所有的老鼠都能够学习辨别方向的任务。这些结果表明，海马体和MCN支持与方向信息的短期记忆相关的过程。
A delayed matching-to-sample task was designed to assess memory for direction information in rats. During the study phase, rats traversed a maze arm oriented in 1 of 3 directions. After a delay period, a test phase was presented that required a choice between the study phase direction and a foil direction. Once rats reached a learning criterion, probe trials suggested that normal rats favor the use of direction, rather than turning response, information and use vestibular feedback. Rats were then given hippocampus, medial caudate nucleus (MCN), or cortical control lesions. Unlike control rats, those with hippocampus and MCN lesions exhibited marked impairments when retested. However, all rats were able to learn a direction discrimination task. These results suggest that the hippocampus and MCN support processes associated with short-term memory for direction information.