18-fluorodeoxyglucose positron emission tomography has limited sensitivity for colonic adenoma and early stage colon cancer
18-fluorodeoxyglucose positron emission tomography has limited sensitivity for colonic adenoma and early stage colon cancer
复制标题
DOI：
10.1016/s0016-5107(04)02775-0
复制
发表时间：
2005-03-01
影响因子：
7.7
通讯作者：
Segall, G
中科院分区：
文献类型：
--
作者：
Friedland, S;Soetikno, R;Segall, G
背景资料：18-氟脱氧葡萄糖正电子发射断层扫描（PET）在临床上用于检测结肠癌术后复发，但PET对癌前病变和早期结肠癌的敏感性尚不明确。方法：在一项前瞻性研究中，45例患者共58个结肠肿瘤，包括癌前息肉、癌前病变、扁平病变和早期癌症，通过PET进行了评价。PET对肿瘤的敏感性为62%（8/13）。PET检测到100%（7/7）的2 cm或更大的癌症，但只有17%（1/6）的小于2 cm的癌症。PET检测到23%（3/13）的平坦癌前病变; 70%（7/10）的突出癌前病变3 cm或更大; 3/8%（3/8）的突出癌前病变2 - 2.9 cm; 14%（2/14）的突出癌前病变1 - 1.9 cm。PET阅读无假阳性。结论：PET对扁平癌前病变、小于3 cm的突出癌前病变和小于2 cm的结肠癌的敏感性有限。
Background: 18-Fluorodeoxyglucose positron emission tomography (PET) is used clinically to detect recurrent colon cancer after surgical resection, but the sensitivity of PET for premalignant colon lesions and early stage colon cancer is not well defined.Methods: In a prospective study, 45 patients with a total of 58 colonic neoplasms, including premalignant polyps, premalignant, flat lesions, and early stage cancers, were evaluated by PETResults: The sensitivity of PET for cancer was 62% (8/13). PET detected 100% (7/7) of cancers 2 cm or larger but only 17% (1/6) of cancers smaller than 2 cm. PET detected 23% (3/13) of flat, premalignant lesions; 70% (7/10) of protruded, premalignant lesions 3 cm or larger; 38% (3/8) of protruded, premalignant lesions between 2 and 2.9 cm; and 14% (2/14) of protruded, premalignant lesions between 1 and 1.9 cm. There was no false-positive PET reading.Conclusions: PET has limited sensitivity for flat, premalignant lesions; protruded, premalignant lesions smaller than 3 cm; and colon cancers smaller than 2 cm.