BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.
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DOI：
10.1007/s10571-017-0510-4
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发表时间：
2018-04
影响因子：
4
通讯作者：
Moryś J
中科院分区：
文献类型：
--
作者：
Kowiański P;Lietzau G;Czuba E;Waśkow M;Steliga A;Moryś J
脑源性神经营养因子(BDNF)是哺乳动物脑内分布最广、研究最广泛的神经营养因子之一。在其突出的功能中，人们可以提到控制神经元和神经胶质的发育，神经保护，以及调节短期和长期突触相互作用，这对认知和记忆至关重要。BDNF控制着广泛的过程，其作用有时相互矛盾的效应可以根据其特定的合成模式来解释，该模式包括几个中间的生物活性异构体，与不同类型的受体结合，触发几个信号通路。BDNF的功能必须与脑发育阶段、神经组织的不同细胞成分以及在生理和病理条件下激活的信号转导的分子机制密切相关。在这篇综述中，我们简要总结了关于BDNF对神经生理过程调节的影响的知识现状。强调了BDNF对于未来旨在揭示信号通路激活机制、神经和神经胶质发生以及突触可塑性的研究的重要性。
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in the mammalian brain. Among its prominent functions, one can mention control of neuronal and glial development, neuroprotection, and modulation of both short- and long-lasting synaptic interactions, which are critical for cognition and memory. A wide spectrum of processes are controlled by BDNF, and the sometimes contradictory effects of its action can be explained based on its specific pattern of synthesis, comprising several intermediate biologically active isoforms that bind to different types of receptor, triggering several signaling pathways. The functions of BDNF must be discussed in close relation to the stage of brain development, the different cellular components of nervous tissue, as well as the molecular mechanisms of signal transduction activated under physiological and pathological conditions. In this review, we briefly summarize the current state of knowledge regarding the impact of BDNF on regulation of neurophysiological processes. The importance of BDNF for future studies aimed at disclosing mechanisms of activation of signaling pathways, neuro- and gliogenesis, as well as synaptic plasticity is highlighted.