CHILDREN, AGE AT 1ST BIRTH, AND COLORECTAL-CANCER RISK - DATA FROM THE MELBOURNE COLORECTAL-CANCER STUDY
CHILDREN, AGE AT 1ST BIRTH, AND COLORECTAL-CANCER RISK - DATA FROM THE MELBOURNE COLORECTAL-CANCER STUDY
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DOI：
10.1093/oxfordjournals.aje.a115165
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发表时间：
1989-03-01
影响因子：
5
通讯作者：
WATSON, LF
中科院分区：
文献类型：
--
作者：
KUNE, GA;KUNE, S;WATSON, LF
1980年至1981年，作为在澳大利亚墨尔本进行的一项大型结直肠癌流行病学研究的一部分，获得了675例结直肠癌患者和720名年龄-性别频率匹配的对照组的儿童数量和第一个孩子出生年龄的数据。在结直肠癌方面，有1个或多个子女者的相对危险度(RR)显著低于无子女者(RR=0.6 1，95%可信区间：0.45~0.81，p<；0.001)，在调整生育子女数的同时，随着第一个孩子出生年龄的增加，发生结直肠癌的危险性增加(RR=1.0 3，第一个孩子出生年龄每增加一年，95%CI：1.0 0~1.0 5，p=0.0 2)。在男性和女性中，孩子数量和第一个孩子的出生年龄与结直肠癌风险之间的关系在统计学上没有显着差异。年龄、职业、既往饮食、女性使用口服避孕药和结直肠癌家族史等潜在的混杂因素不影响儿童数量和第一个孩子出生时的结直肠癌风险。由于墨尔本研究发现，男性和女性对结直肠癌的预防与生育孩子和第一个孩子的年龄较早是相似的，生活方式因素，而不是女性荷尔蒙因素，被假设为这些影响的中介因素。
During 1980 and 1981, data were obtained on the number of children and age at birth of the first child in 675 cases of colorectal cancer and in 720 age-sex frequency-matched controls as part of a large epidemiologic study of colorectal cancer conducted in Melbourne, Asutralia. For colorectal cancer, the relative risk (rR) for those with one or more children compared with those with no children was statistically significantly lower than one (RR = 0.61, 95% confidence interval (CI): 0.45-0.81, p < 0.001), and with simultaneous adjustment for number of children, there was an increasing risk with increasing age at birth of first child (RR = 1.03, with each increasing year of age at birth of first child, 95% CI: 1.00-1.05, p = 0.02). The relation between both the number of children and the age at birth of the first child and colorectal cancer risk was not statistically significantly different for males and females. The risk of colorectal cancer with respect to number of children and age at birth of the first child was unaffected by the potential confounding factors of age, occupation, previous diet, oral contraceptive use in females, and a family history of colorectal cancer. Since the protection against colorectal cancer associated with having children and with earlier age at birth of the first child was found to be similar for both males and females in the Melbourne study, a life-style factor, as yet unidentified, rather than a female hormonal factor, is postulated as the mediator of these effects.