No evidence for histamine-mediated morphine analgesia.
No evidence for histamine-mediated morphine analgesia.
复制标题
没有证据表明组胺介导吗啡镇痛。
DOI：
10.1016/0028-3908(84)90169-2
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发表时间：
1984
影响因子：
4.7
通讯作者：
Glick,SD
中科院分区：
文献类型：
--
作者：
Hough,LB;Su,KL;Goldschmidt,RC;Khandelwal,JK;Newton,MV;Glick,SD
A role for brain histamine in the acute action of morphine was studied in mice. In contrast to earlier reports, whole brain histamine levels were not changed 30 min after morphine (1–56 mg/kg). Levels of the brain histamine metabolite, tele-methylhistamine, were also unchanged. Marphine (1.8–10 mg/kg) caused a dose-dependent antinociceptive response that was unaffected by histamine H 1-antagonists (ip), H 2-antagonists (ip or i. vent.), or metoprine (ip), an inhibitor of histamine metabolism. α-Fluoromethylhistidine, the inhibitor of brain histamine synthesis, unexpectedly potentiated the response to low doses of morphine. These results find no evidence for a role of brain histamine in opiate analgesia.
