Effects of ribavirin on neutrophil function.
Effects of ribavirin on neutrophil function.
复制标题
利巴韦林对中性粒细胞功能的影响。
DOI：
10.1097/00000441-198806000-00002
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
R. Charlton
中科院分区：
文献类型：
--
作者：
R. W. Steele;D. Crosby;R. W. Steele;N. S. Pilkington;R. Charlton
利巴韦林是一种广谱抗病毒药物，具有免疫抑制活性。这种特性在临床试验中引起了人们的关注，因为抗病毒治疗的候选者是那些可能发生继发性细菌感染的人。因此，我们研究了一些参数的中性粒细胞功能后，在体外添加不同浓度的利巴韦林。在药理浓度（1.25-7.5微克/毫升）下，通过丫啶橙子荧光染料微量测定法测量，吞噬细菌的杀伤百分比增加，在5微克/毫升浓度下显着更高（p小于0.02）。对粘附、随机迁移、趋化性、调理作用或吞噬作用没有伴随的不良影响。目前的数据表明，利巴韦林对粒细胞功能没有急性抑制作用，甚至可以增强治疗患者的细菌杀灭能力。
Ribavirin, a broad spectrum antiviral agent, has been shown to exhibit immunosuppressive activity. This property has raised concerns during clinical trials because candidates for antiviral therapy are those who may develop secondary bacterial infection. We therefore investigated a number of parameters of neutrophil function after the in vitro addition of various concentrations of ribavirin. At pharmacologic concentrations (1.25-7.5 micrograms/mL), percent killing of phagocytized bacteria was increased as measured by an acridine orange fluorochrome microassay, significantly higher at a concentration of 5 micrograms/mL (p less than .02). There was no concomitant adverse effect on adherence, random migration, chemotaxis, opsonization or phagocytosis. The present data indicate that ribavirin has no acute suppressive effect on granulocyte function and may even enhance bacterial killing capabilities for treated patients.
利巴韦林气雾剂治疗婴儿呼吸道合胞病毒感染相关的细支气管炎。
影响因子：
8
作者：
Taber,LH;Knight,V;Gilbert,BE;McClung,HW;Wilson,SZ;Norton,HJ;Thurson,JM;Gordon,WH;Atmar,RL;Schlaudt,WR
通讯作者：
Schlaudt,WR