Reproduction of hemangioma by infection with subgroup J avian leukosis virus: the vertical transmission is more hazardous than the horizontal way.
Reproduction of hemangioma by infection with subgroup J avian leukosis virus: the vertical transmission is more hazardous than the horizontal way.
复制标题
DOI：
10.1186/1743-422x-10-97
复制
发表时间：
2013-03-27
期刊：
影响因子：
4.8
通讯作者：
Huang Y
中科院分区：
文献类型：
--
作者：
Lin Y;Xia J;Zhao Y;Wang F;Yu S;Zou N;Wen X;Cao S;Huang Y
自2006年以来，在商业化鸡群中已经报道了与J亚群禽白血病病毒（ALV-J）相关的血管瘤临床病例。本研究通过ALV-J感染蛋鸡，复制血管瘤，以评价ALV-J对蛋鸡及其后代的致病性。感染ALV-J株SCDY 1的雏鸡体重和免疫器官指数均低于对照组。在许多组织中观察到淋巴细胞增殖，并且在感染后14天在淋巴细胞基因组中检测到病毒整合，沿着病毒脱落。ALV-J也能有效地从卵传播到后代。胚胎孵化率和子代死亡率均低于对照组。子代淋巴细胞的排毒效率和病毒整合效率均高于亲本。ALV-J能抑制感染鸡的生长，并对免疫器官造成损害。ALV-J的垂直传播似乎比水平传播更有害。
Clinical cases of hemangioma associated with subgroup J avian leukosis virus (ALV-J) have been reported in commercial chicken layer flocks since 2006. We attempted to reproduce hemangioma through experimental infection with ALV-J to evaluate viral pathogenicity in layer birds and their progenies. Body weight and indexes for immune organs of chickens infected with ALV-J strain SCDY1 were lower than those in controls. Proliferation of lymphocytes was observed in many tissues, and viral integration was detected in the genome of lymphocytes at 14 days post-infection, along with virus shedding. ALV-J was also efficiently transmitted from eggs to progenies. Embryo hatchability and progeny mortality were lower than those for controls. The efficiencies of virus shedding and virus integration in the lymphocytes of progenies were higher than those in parents. ALV-J is able to inhibit the growth of infected chickens, and causes damage to immune organs. Vertical transmission of ALV-J appears to be more deleterious than horizontal transmission.