Recent Thymic Emigrants (CD4+) Continuously Migrate Through Lymphoid Organs: within the Tissue They Alter Surface Molecule Expression
Recent Thymic Emigrants (CD4+) Continuously Migrate Through Lymphoid Organs: within the Tissue They Alter Surface Molecule Expression
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最近的胸腺迁移者 (CD4) 不断迁移通过淋巴器官：在组织内它们改变表面分子表达
DOI：
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发表时间：
2001
影响因子：
3.7
通讯作者：
J. Westermann
中科院分区：
文献类型：
--
作者：
B. Luettig;A. Sponholz;C. Heerwagen;U. Bode;J. Westermann
T细胞祖细胞从骨髓（BM）迁移到胸腺中。成熟后，它们作为最近的胸腺移民（RTE）释放到外周，确保T细胞库的多样化。RTE通过外周迁移的动力学和它们表达的表面分子都还不清楚。在1月龄和18月龄刘易斯大鼠中，通过流式细胞术（CD 45 RC −和CD 90+）在血液、脾脏、淋巴结和胸导管淋巴中鉴定出CD 4 + RTE，并将其与CD 4+初始T细胞（CD 45 RC+）和记忆T细胞（CD 45 RC − CD 90 −）区分开来，并对表面分子的表达进行表征。在1月龄和18月龄动物中，血液中CD 4+群体的RTE百分比与所有其他隔室中的RTE百分比相当。令人惊讶的是，RTE表达α4-整联蛋白、LFA-1和白细胞介素（IL）-2受体的水平显著高于初始T细胞，与记忆T细胞更相似。在淋巴组织RTE中，初始和记忆T细胞显著上调CD 44和ICAM-1的表达，并下调L-选择素的表达。这些变化在细胞重新进入血液之前被逆转。因此，我们的数据表明，CD 4 + RTE像成熟T细胞一样穿过年轻和老年大鼠的外周，不断调节其表面分子的表达。
T‐cell progenitors migrate from bone marrow (BM) into the thymus. After maturation they are released as recent thymic emigrants (RTE) into the periphery ensuring the diversification of the T‐cell repertoire. Both the kinetics with which RTE migrate through the periphery and the surface molecules they express are still unclear. In 1‐ and 18‐month‐old Lewis rats CD4+ RTE were identified in blood, spleen, lymph node, and thoracic duct lymph by flow cytometry (CD45RC− and CD90+), were differentiated from CD4+ naive (CD45RC+) and memory T cells (CD45RC−CD90−), and were characterized regarding the expression of surface molecules. Both in 1‐ and 18‐month‐old animals the percentage of RTE among the CD4+ population in blood was comparable to that in all other compartments. Surprisingly, RTE expressed α4‐integrin, LFA‐1, and interleukin (IL)‐2 receptor at a significantly higher level than naive T cells and more comparable to memory T cells. Within lymphoid tissues RTE, naive, and memory T cells significantly upregulated the expression of CD44 and ICAM‐1, and downregulated the expression of l‐selectin. These changes were reversed before the cells re‐entered the blood. Thus, our data indicate that CD4+ RTE travel through the periphery of young and old rats like mature T cells, continuously modulating their surface molecule expression.
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影响因子：
4.4
作者：
J. Allport;H. Ding;A. Ager;D. Steeber;T. Tedder;F. Luscinskas
通讯作者：
J. Allport;H. Ding;A. Ager;D. Steeber;T. Tedder;F. Luscinskas
DOI：
10.1016/0167-5699(95)80179-0
发表时间：
1995-06-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
SCOLLAY, R;GODFREY, DI
通讯作者：
GODFREY, DI
大鼠中最近的胸腺移出物表达独特的抗原表型，并在外周淋巴组织中经历胸腺后成熟。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hosseinzadeh,H;Goldschneider,I
通讯作者：
Goldschneider,I
易患淋巴细胞减少型糖尿病的 BioBreeding 大鼠肝脏中最近胸腺迁移的高频细胞凋亡。
DOI：
--
发表时间：
1998
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Iwakoshi,NN;Goldschneider,I;Tausche,F;Mordes,JP;Rossini,AA;Greiner,DL
通讯作者：
Greiner,DL