Controlling the Diameters of Nanotubes Self-Assembled from Designed Peptide Bolaphiles
Controlling the Diameters of Nanotubes Self-Assembled from Designed Peptide Bolaphiles
复制标题
控制由设计的肽 Bolaphiles 自组装的纳米管的直径
DOI：
10.1002/smll.201703216
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发表时间：
2018-03-22
期刊：
影响因子：
13.3
通讯作者：
Xu, Hai
中科院分区：
文献类型：
--
作者：
Zhao, Yurong;Yang, Wei;Xu, Hai
控制纳米管的直径是从模板分子自组装纳米结构的主要挑战。在此，设计了两个系列的bola型六肽，组I由Ac-KI 4K-NH 2、Ac-KI（3）NleK-NH 2、Ac-KI 3LK-NH 2和Ac-KI（3）TleK-NH 2组成，组II由Ac-KI 3VK-NH 2、Ac-KI 2 V2 K-NH 2、Ac-KI 3 K-NH 2和Ac-KI 4K-NH 2组成。在组I中，在C-末端替换Ile改变了其侧链分支，但保留了疏水性。在第二组中，瓦尔取代Ile导致疏水性降低，但保留了侧链分支。肽亲氢体倾向于形成长的纳米管，其中管壳由肽单层组成。核心侧链分支和疏水性的变化导致肽纳米管直径从超过一百纳米到几纳米的稳定变化，从而实现对潜在分子自组装过程的可靠控制。鉴于不同尺寸的肽管在自然界和技术应用中的结构和功能作用，本研究阐明了短肽自组装纳米结构的预测模板。
Controlling the diameters of nanotubes represents a major challenge in nanostructures self-assembled from templating molecules. Here, two series of bolaform hexapeptides are designed, with Set I consisting of Ac-KI4K-NH2, Ac-KI(3)NleK-NH2, Ac-KI3LK-NH2 and Ac-KI(3)TleK-NH2, and Set II consisting of Ac-KI3VK-NH2, Ac-KI2V2K-NH2, Ac-KIV3K-NH2 and Ac-KV4K-NH2. In Set I, substitution for Ile in the C-terminal alters its side-chain branching, but the hydrophobicity is retained. In Set II, the substitution of Val for Ile leads to thedecrease of hydrophobicity, but the side-chain -branching is retained. The peptide bolaphiles tend to form long nanotubes, with the tube shell being composed of a peptide monolayer. Variation in core side-chain branching and hydrophobicity causes a steady shift of peptide nanotube diameters from more than one hundred to several nanometers, thereby achieving a reliable control over the underlying molecular self-assembling processes. Given the structural and functional roles of peptide tubes with varying dimensions in nature and in technological applications, this study exemplifies the predictive templating of nanostructures from short peptide self-assembly.