DOES SHORT-TERM VITAMIN C REDUCE CARDIOVASCULAR RISK IN TYPE 2 DIABETES?
DOES SHORT-TERM VITAMIN C REDUCE CARDIOVASCULAR RISK IN TYPE 2 DIABETES?
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DOI：
10.4158/ep12431.or
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发表时间：
2013-09-01
影响因子：
4.2
通讯作者：
Schade, David S.
中科院分区：
文献类型：
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作者：
Gutierrez, Absalon D.;Duran-Valdez, Elizabeth;Schade, David S.
目的：维生素C是一种有效的抗氧化剂，对预防糖尿病患者动脉粥样硬化有潜在的作用。然而，维生素C体内抗动脉粥样硬化作用的机制尚未解决，在非糖尿病个体中的临床试验产生了相互矛盾的结果。因此，我们在8名2型糖尿病志愿者中进行了32项随机、交叉、剂量反应试验，以确定维生素C对血清维生素C水平、血脂、炎症和凝血功能的影响。1）不补充维生素C，2）低剂量维生素C（250 mg/天），3）中剂量维生素C（500 mg/天），4）高剂量维生素C（1,000 mg/天）。在每个研究组期间摄入高热量午餐以增强氧化应激。血清维生素C水平和动脉粥样硬化的危险因素，包括脂质和氧化应激，炎症和高凝状态的标志物determined.Results：血清维生素C水平在所有剂量显着增加。此外，高热量膳食导致葡萄糖、胰岛素和甘油三酯在餐后数小时内急性升高。然而，没有观察到维生素C对脂质参数或任何氧化应激，炎症，或hypercoagulation.Conclusion的替代标志物的显着影响：我们的研究表明，如果维生素C确实具有抗动脉粥样硬化作用的糖尿病，它不发挥他们通过传统的途径确定的替代标志物的心血管风险。
Objective: Vitamin C is a powerful antioxidant that is potentially useful in the prevention of atherosclerosis in diabetic individuals. However, the mechanism(s) of vitamin C's anti-atherosclerotic effects in vivo are unresolved, and clinical trials in nondiabetic individuals have yielded conflicting results. Therefore, we performed 32 studies in a randomized, crossover, dose-response trial in 8 volunteers with type 2 diabetes to determine the effects of vitamin C on serum vitamin C levels, lipids, inflammation, and coagulation.Methods: Well-controlled, type 2 volunteers received, in randomized order for 2-week periods, each of the following: 1) no supplemental vitamin C, 2) low-dose vitamin C (250 mg/day), 3) medium-dose vitamin C (500 mg/day), and 4) high-dose vitamin C (1,000 mg/day). A highcaloric content lunch was ingested during each study arm to enhance oxidative stress. Serum vitamin C levels and atherosclerotic risk factors including lipids and markers of oxidative stress, inflammation, and hypercoagulation were determined.Results: Serum vitamin C levels increased significantly at all dosages. In addition, the high-caloric content meal resulted in acute elevations of glucose, insulin, and triglycerides for several hours postmeal. However, no significant effect of vitamin C was observed on lipid parameters or any of the surrogate markers of oxidative stress, inflammation, or hypercoagulability.Conclusion: Our study suggests that if vitamin C does have anti-atherosclerotic effects in diabetes, it does not exert them through the traditional pathways identifiable by established surrogate markers of cardiovascular risk.