CONTRACTILE STATE OF LEFT-VENTRICLE IN MAN AS EVALUATED FROM END-SYSTOLIC PRESSURE-VOLUME RELATIONS
CONTRACTILE STATE OF LEFT-VENTRICLE IN MAN AS EVALUATED FROM END-SYSTOLIC PRESSURE-VOLUME RELATIONS
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DOI：
10.1161/01.cir.56.5.845
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发表时间：
1977-01-01
期刊：
影响因子：
37.8
通讯作者：
GREEN, LH
中科院分区：
文献类型：
--
作者：
GROSSMAN, W;BRAUNWALD, E;GREEN, LH
本文对24例不同程度左室功能不全者进行了心导管检查，测定了左室收缩末期压（PES）、容积（VES）、室壁张力（TES）和周长（CES）。收缩负荷的急性变化一致导致VES和CES的变化，每个受试者的收缩负荷较低的特征是体积和周长较小。通过绘制每个受试者在较高和较低收缩负荷下PES与VES的关系来构建收缩末期压力-容积线。结果显示，正常左心室的斜率比收缩不良左心室的斜率要陡得多。Vo是线的体积轴截距（即，PES = 0时的理论VES对于正常心室比对于收缩不良的心室显著更小。在收缩末期室壁张力为零时的理论收缩末期周长Co也观察到类似的结果。期外收缩后增强导致VES和CES降低，PES无变化，TES仅轻微下降。收缩末期压力-容积和张力-周长关系反映了左室心肌的收缩状态。这些关系的定量可能提供一个有用的新的方法来评估心肌功能的人。
End-systolic pressure (PES), volume (VES), wall tension (TES) and circumference (CES) of the human left ventricle were studied at cardiac catheterization in 24 subjects with varying degrees of left ventricular dysfunction. Acute alterations in systolic load consistently resulted in changes in VES and CES, with a small volume and circumference characterizing the lower systolic load in each subject. End systolic pressure-volume lines were constructed by plotting PES against VES at the higher and lower systolic load in each subject. The slope of the resultant lines was considerably steeper for normal than for poorly contractile left ventricles. Vo, the volume axis intercept of the line (i.e., the theoretical VES at PES = O), was significantly smaller for normal than for poorly contractile ventricles. Similar findings were noted for Co, the theoretic end-systolic circumference at zero end-systolic ventricular wall tension. Post-extrasystolic potentiation resulted in decreased VES and CES, with no change in PES and only a slight fall in TES. End-systolic pressure-volume and tension-circumference relations reflect the contractile state of left ventricular myocardium. Quantitation of these relationships may provide a useful new approach to the assessment of myocardial function in man.