Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children
Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children
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DOI：
10.1111/j.1365-2230.2004.01501.x
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发表时间：
2004-05-01
影响因子：
4.1
通讯作者：
Fok, TF
中科院分区：
文献类型：
--
作者：
Hon, KLE;Leung, TF;Fok, TF
至少有13种评分系统用于评估特应性皮炎（AD）的疾病严重程度。每个系统都有其观察者间和观察者内变异性的问题。皮肤T细胞趋化因子（CTACK）是一种皮肤特异性趋化因子，可能与AD的严重程度相关，并解决了观察者可靠性的问题。我们根据特应性皮炎评分（SCORAD）指数评估血清CTACK浓度是否与儿童AD的严重程度相关。37名中国AD儿童（23名男孩，14名女孩;年龄1-11岁）和13名对照。AD患者的总体SCORAD中位数（四分位距）为29.7（20.3-49.7）。用夹心酶免疫法测定CTACK和其他两种过敏性相关趋化因子，巨噬细胞衍生趋化因子（MDC）和胸腺和活化调节趋化因子（TARC）的血清浓度。SCORAD（r = 0.394，P = 0.016）、其面积（r = 0.528，P = 0.001）和强度分量（r = 0.429，P = 0.008）与血清CTACK水平呈显著相关。血清炎症标志物MDC和TARC浓度与CTACK浓度相关（分别为r = 0.618，P < 0.001和r = 0.587，P = 0.001）。血清CTACK浓度似乎是与AD的各种临床和实验室参数相关的皮肤特异性客观标志物。
There are at least 13 scoring systems for the assessment of disease severity in atopic dermatitis (AD). Each system has its problems with interobserver and intraobserver variability. Cutaneous T-cell attracting chemokine (CTACK) is a skin-specific chemoattractant which may correlate with AD severity and obviate the issue of observer reliability. We evaluated whether serum CTACK concentrations were associated with the severity of AD in children according to the SCORing Atopic Dermatitis (SCORAD) index. Thirty-seven Chinese children with AD (23 boys, 14 girls; aged 1-11 years) and 13 controls were recruited. The median (interquartile range) overall SCORAD for AD patients was 29.7 (20.3-49.7). Serum concentrations of CTACK and two other atopy-related chemokines, macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC), were measured by sandwich enzyme immunoassay. There were significant correlations between SCORAD (r = 0.394, P = 0.016), its area (r = 0.528, P = 0.001) and intensity components (r = 0.429, P = 0.008) with serum levels of CTACK. The serum concentrations of inflammatory markers MDC and TARC also correlated with the CTACK concentrations (r = 0.618, P < 0.001, and r = 0.587, P = 0.001, respectively). Serum CTACK concentration appears to be a skin-specific objective marker that correlates with various clinical and laboratory parameters of AD.