Pharmacotherapy for severe aggression in a child with autism: "open label" evaluation of multiple medications on response frequency and intensity of behavioral intervention
Pharmacotherapy for severe aggression in a child with autism: "open label" evaluation of multiple medications on response frequency and intensity of behavioral intervention
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DOI：
10.1016/s0005-7916(01)00007-6
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发表时间：
2000-09-01
影响因子：
1.8
通讯作者：
Holzman, T
中科院分区：
文献类型：
--
作者：
Luiselli, JK;Blew, P;Holzman, T
许多有发育障碍和挑战性行为的人接受多种药物联合非药物方法治疗。然而，药物治疗的比较效果通常没有经验性评估，不包括必然的行为措施，也没有长期评估。本单例研究纳入行为评估方法，在“开放标签”评价抗惊厥药（氯硝西泮），β-阻滞剂（心得安），和抗抑郁药（舍曲林和氯硝帕明）的严重侵略自闭症儿童的药物。临床上显着减少攻击性行为，达到与管理的氯硝帕明和减少的影响，从药物持续了1.7年。此外，氯硝帕明与消除危机干预程序有关，这些程序是管理儿童攻击性所必需的。这些发现补充了临床文献，描述了使用抗抑郁药物治疗发育障碍患者严重行为障碍的有效治疗。(C)2001爱思唯尔科技有限公司版权所有。
Many persons who have developmental disabilities and challenging behaviors are treated with multiple medications combined with nonpharmacological approaches. However, the comparative effects from pharmacotherapy frequently are not assessed empirically, do not include corollary behavioral measures, and are not evaluated in the long term. The present single-case study incorporated behavioral assessment methodology in an "open label" evaluation of anticonvulsant (clonazepam), beta-blocking (propanolol), and antidepressant (sertraline and clornipramine) medications on severe aggression in a child with autism. Clinically significant reductions in aggressive behavior were attained with the administration of clornipramine and the reductive effects from the medication persisted for 1.7 years. In addition, clornipramine was associated with the elimination of crisis intervention procedures that had been required to manage the child's aggression. These findings add to the clinical literature describing effective treatment of serious behavior disorders in persons with developmental disabilities using antidepressant medication. (C) 2001 Elsevier Science Ltd. All rights reserved.