Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.
Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.
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DOI：
10.1038/srep28484
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发表时间：
2016-06-27
影响因子：
4.6
通讯作者：
Mangalam AK
中科院分区：
文献类型：
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作者：
Chen J;Chia N;Kalari KR;Yao JZ;Novotna M;Paz Soldan MM;Luckey DH;Marietta EV;Jeraldo PR;Chen X;Weinshenker BG;Rodriguez M;Kantarci OH;Nelson H;Murray JA;Mangalam AK
多发性硬化（MS）是一种免疫介导的疾病，其病因涉及遗传和环境因素。导致MS易感性的环境因素的确切性质仍然难以捉摸;然而，据推测，胃肠道微生物群可能在MS发病机制中起重要作用。因此，本研究旨在通过比较复发缓解型MS（RRMS）患者（n = 31）与年龄和性别匹配的健康对照者（n = 36）。使用16 S核糖体RNA基因的V3-V5区的高变标签测序生成肠道微生物种群的系统发育谱。详细的粪便微生物组分析显示，与健康对照相比，MS患者具有不同的微生物群落特征。我们观察到MS患者中伪单胞菌属、支原体属、嗜血杆菌属、布劳特氏菌属和多雷氏菌属的丰度增加，而对照组显示副拟杆菌属、阿得克罗伊茨菌属和普雷沃氏菌属的丰度增加。因此，我们的研究与MS患者存在肠道微生物生态失调的假设一致，需要进一步研究以更好地了解它们在MS发病机制中的作用。
Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3–V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.