GROWTH VELOCITY IN VERY LOW BIRTH WEIGHT INFANTS. ARE THE REFERENCE GROWTH CHARTS APPROPRIATE?
GROWTH VELOCITY IN VERY LOW BIRTH WEIGHT INFANTS. ARE THE REFERENCE GROWTH CHARTS APPROPRIATE?
复制标题
极低出生体重婴儿的生长速度。
作者：
C. Fustiñana;J. C. Cernadas;L. Lieva
极低出生体重儿（VLBWI）的生长发育通常采用标准参考曲线（SRC）进行评价。这些图表是由产前生长曲线到足月（横断面研究），然后是足月健康婴儿的纳塔尔后纵向生长图表组成的。我们的目的是比较SRC的生长速度与身高，体重和头围生长速度的人口35 VLBWI低新生儿发病率和足够的体重胎龄，谁被随访一年的校正年龄。该人群的出生体重（[xmacr ] ± SD）：1290 ± 150，身长：38.3 ± 2.8，头围：26.3 ± 1.3，胎龄：30 ± 1.3周。三个参数的加速生长期呈二次回归关系（抛物线），与SRC相比，体重的顶点延迟4周，头围和体长延迟5周，它的幅度要大得多SRC组（体重和身长）与VLBWI组相比（350 g ± 80 vs 270 ± 90和1.3 ± 0.2 vs 1.02 ± 0.1），差异有显著性（p < 0.01）。VLBWI的生长速度增加持续到矫正龄6个月，而不像SRC只持续到足月。我们的结果表明，在早产儿快速生长期的临床评估中，SRC不能充分反映这一关键时期的生长速度变化。
Growth of very low birth weight infants (VLBWI) is usually assesed by Standard Reference Curves (SRC). These chars are composed by prenatal growth curves up to term (cross sectional studies) followed by post natal longitudinal growth charts of fullterm healthy babies. Our purpose was to compare the growth velocity of SRC with the lenght, weight and head circumference growth velocity of a population of 35 VLBWI with low neonatal morbidity and adequate weight for gestational age, who were followed up for one year of corrected age. Birth weight of this population was ([xmacr ] ± SD): 1290 ± 150, lenght: 38.3 ± 2.8, head circumference: 26.3 ± 1.3 and gestational age: 30 ± 1.3 weeks. The accelerated growth period of the three parameters showed a quadratic regression (parabola), with its acme retarded 4 weeks compared to SRC for weight and 5 weeks for head circumference and body lenght, its magnitude being significantly greater (p < 0.01) in the SRC (for weight and lenght) than in the VLBWI (350g ± 80 vs 270 ± 90 and 1.3 ± 0.2 vs 1.02 ± 0.1). Total accumulated growth at one year was similar in both curves.Increased growth velocity in VLBWI lasted until six months of corrected age and not up to full term only as in SRC. Our results suggest that for clinical assessement of rapid growth period in premature infants, SRC do not adequately reflect changes in growth velocity during this critical period.