Multifunctional self-assembled polymeric nanoprobes for FRET-based ratiometric detection of mitochondrial H2O2 in living cells
Multifunctional self-assembled polymeric nanoprobes for FRET-based ratiometric detection of mitochondrial H2O2 in living cells
复制标题
多功能自组装聚合物纳米探针，用于活细胞中线粒体 H2O2 的基于 FRET 的比例检测
DOI：
10.1039/c4cc09120e
复制
发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Niu, Zhongwei
中科院分区：
文献类型：
--
作者：
Qiao, Jing;Liu, Zhi;Niu, Zhongwei
一个比例，多功能纳米探针的制备组成的自组装聚合物胶束作为载体，四苯乙烯（TPE）作为供体，荧光硼酸作为H2O2响应受体，和三苯基膦作为一个靶向的部分。组装的纳米颗粒可以检测活细胞中外源性和内源性线粒体H2O2的变化。
A ratiometric, multifunctional nanoprobe was prepared consisting of a self-assembled polymeric micelle as the carrier, tetraphenylethene (TPE) as the donor, fluorescent boronate as the H2O2-responsive acceptor, and triphenylphosphonium as a mitochondria-targeted moiety. The assembled nanoparticles could detect both exogenous and endogenous mitochondrial H2O2 changes in living cells.