HIGH INHIBITORY ACTIVITY OF CERTAIN HALOGENATED RIBOFURANOSYLBENZIMIDAZOLES ON INFLUENZA B VIRUS MULTIPLICATION
HIGH INHIBITORY ACTIVITY OF CERTAIN HALOGENATED RIBOFURANOSYLBENZIMIDAZOLES ON INFLUENZA B VIRUS MULTIPLICATION
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某些卤代呋喃核糖基苯并咪唑对 B 型流感病毒增殖的高抑制活性
DOI：
10.1128/jb.72.1.54-58.1956
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发表时间：
1956
影响因子：
3.2
通讯作者：
C. H. Shunk
中科院分区：
文献类型：
--
作者：
I. Tamm;K. Folkers;C. H. Shunk
早期的研究（Tamm等人，1954年; Tamm，1954）表明，通过用咪唑环中Ni处存在的fT-D-呋喃核糖多次取代苯环上的氯原子，可以产生对流感和腮腺炎病毒增殖具有非常高抑制活性的苯并咪唑衍生物。在随后的报告（Tarm，1955; Tamm，1956）中，有证据表明，氯代呋喃核糖基衍生物表现出的中等程度的作用选择性是由于咪唑环中Ni处存在f3-n-呋喃核糖。本报告涉及的某些氯，溴，碘的苯并咪唑衍生物和相应的呋喃核糖核苷对流感病毒的增殖在体外培养的绒毛尿囊膜B病毒的抑制活性。比较了几种卤代呋喃核糖基苯并咪唑类化合物的抑制活性.这些化合物作为流感B病毒增殖抑制剂的作用选择性是确定的。
Earlier studies (Tamm et al., 1954; Tamm, 1954) showed that benzimidazole derivatives of very high inhibitory activity on influenza and mumps virus multiplication could be produced by multiple substitution of chlorine atoms in the benzenoid ring with ft-D-ribofuranose present at Ni in the imidazole ring. In subsequent reports (Tarm, 1955; Tamm, 1956) evidence was presented to show that the moderate degree of selectivity of action exhibited by chloro-ribofuranosyl derivatives was due to the presence of f3-n-ribofuranose at Ni in the imidazole ring. The present report concerns the inhibitory activity of certain chloro, bromo, and iodo derivatives of benzimidazole and that of the corresponding ribofuranosides on the multiplication of influenza B virus in chorioallantoic membrane cultures in vitro. The inhibitory activity of certain halogenated aor ,-linked ribofuranosylbenzimidazoles is compared. The selectivity of action of these compounds as inhibitors of influenza B virus multiplication is asseed.