Microglial phagocytosis of live neurons
Microglial phagocytosis of live neurons
复制标题
DOI：
10.1038/nrn3710
复制
发表时间：
2014-04-01
影响因子：
34.7
通讯作者：
Neher, Jonas J.
中科院分区：
文献类型：
--
作者：
Brown, Guy C.;Neher, Jonas J.
小胶质细胞是大脑的专职吞噬细胞，可以清除死亡和垂死的神经元以及活神经元的突触和突起。然而，我们和其他人最近发现，小胶质细胞也可以通过吞噬应激但存活的神经元来执行神经元死亡-我们称之为吞噬作用。在这篇进展文章中，我们讨论的证据表明，吞噬可能有助于在大脑发育，炎症，缺血和神经变性的神经元损失。
Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well as synapses and the processes of live neurons. However, we and others have recently shown that microglia can also execute neuronal death by phagocytosing stressed-but-viable neurons - a process that we have termed phagoptosis. In this Progress article, we discuss evidence suggesting that phagoptosis may contribute to neuronal loss during brain development, inflammation, ischaemia and neurodegeneration.