A new approach to understand the pathophysiology of Parkinson's disease
A new approach to understand the pathophysiology of Parkinson's disease
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DOI：
10.1007/s00415-005-4002-y
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发表时间：
2005-10-01
影响因子：
6
通讯作者：
Nambu, A
中科院分区：
文献类型：
--
作者：
Nambu, A
在这里，我介绍了一个控制自主运动的基础神经节功能的动态模型：通过皮质-基底节环中的主要通路，即皮质-STN-GPI/SNR“超直接”通路、皮质-纹状体-GPI/SNR“直接”通路和皮质-纹状体-GPE-STN-GPI/SNR“间接”通路，动态地控制丘脑和皮质的活动，并在选定的时间只释放选定的运动程序。基于动态模型，帕金森病的病理生理机制和立体定向手术的有效机制可以更好地用丘脑和皮质的去抑制和抑制在时间和空间域中的增加或减少来解释。
Here I introduce a dynamic model of the basal ganglia functions for the control of voluntary movement: information through major pathways in the cortico-basal ganglia loop, i.e., the cortico-STN-GPi/SNr "hyperdirect", cortico-striato-GPi/SNr "direct" and cortico-striato-GPe-STN-GPi/SNr "indirect" pathways, dynamically controls the activity of the thalamus and cortex and releases only the selected motor program at the selected timing. Based on the dynamic model, the pathophysiology of Parkinson's disease and the mechanism for the effectiveness of stereotaxic surgery can better be explained by an increase or decrease of disinhibition and inhibition in the thalamus and cortex in the temporal and spatial domains.