Design of novel starch-based Pickering emulsions as platforms for skin photoprotection
Design of novel starch-based Pickering emulsions as platforms for skin photoprotection
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DOI：
10.1016/j.jphotobiol.2016.06.026
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发表时间：
2016-09-01
影响因子：
5.4
通讯作者：
Ribeiro, H. M.
中科院分区：
文献类型：
--
作者：
Marto, J.;Gouveia, L. F.;Ribeiro, H. M.
最近发现，绿咖啡油和变性淀粉对紫外线辐射有增强的保护作用。因此，本研究旨在开发一种基于皮克林乳液概念的创新防晒霜配方，即由物理紫外线过滤器和天然油脂稳定的无表面活性剂乳液，作为预防紫外线引起的皮肤损伤的关键策略。通过严格的药物控制，对不同组成的皮克林乳剂的pH、机械、物理和微生物稳定性进行了表征。此外，防晒系数（SPF）以及最终配方的体外和体内生物学特性，包括Episkin， HRIPT和防晒霜的耐水性。配方研究表明，添加物理紫外线过滤器是有益的，导致ZnO和TiO2的包含，以确保对UVA和UVB分别具有高SPF。虽然淀粉颗粒没有固有的光防护性能，但它们通过协同效应被证明是SPF促进剂。绿咖啡油被选择为天然油，因为与其他天然油相比，它的SPF值最高。除了体外和体内实验结果证实的优异防晒活性外，根据整个研究期间（3个月）的流变学评估和稳定性，最终配方也被证明适合局部使用。综上所述，三种多功能固体颗粒和绿咖啡油的结合，有助于实现稳定有效的创新防晒霜，具有广泛的紫外线防护。(C) 2016 Elsevier B.V.版权所有
Green coffee oil and modified starch were recently found to have an enhanced protection effect against UV radiation. Therefore, this work aimed to develop an innovative sunscreen formulation based on Pickering emulsions concept, i.e., surfactant-free emulsions stabilized by physical UV filters associated natural oils as a key strategy for prevention against UV-induced skin damage.The Pickering emulsions of different compositions were characterized in terms of pH, mechanical, physical and microbiological stability by a thorough pharmaceutical control. In addition, the sun protection factor (SPF) as well as the in vitro and in vivo biological properties of the final formulations, including Episkin, HRIPT and sunscreen water resistance.Formulation studies demonstrated the addition of physical UV filters was beneficial, leading to the inclusion of ZnO and TiO2 to ensure a high SPF against UVA and UVB, respectively. Although starch particles presented no intrinsic photoprotection properties, they proved to be a SPF promoter by a synergistic effect. Green coffee oil was the selected natural oil due to the highest SPF, when compared to other natural oils tested. Besides the excellent sunscreen activity confirmed by in vitro and in vivo results, the final formulations proved to be also suitable for topical use according to the rheological assessment and stability throughout the study period (3 months). In conclusion, the combination of three multifunctional solid particles and green coffee oil, contributed to achieve a stable and effective innovative sunscreen with a wide range of UV radiation protection. (C) 2016 Elsevier B.V. All rights reserved.