Prevalence of Ventricular Arrhythmia and Its Associated Factors in Nondialyzed Chronic Kidney Disease Patients
Prevalence of Ventricular Arrhythmia and Its Associated Factors in Nondialyzed Chronic Kidney Disease Patients
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DOI：
10.1371/journal.pone.0066036
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发表时间：
2013-06-07
期刊：
影响因子：
3.7
通讯作者：
Fernandes Canziani, Maria Eugenia
中科院分区：
文献类型：
--
作者：
Bastos Bonato, Fabiana Oliveira;Lemos, Marcelo Montebello;Fernandes Canziani, Maria Eugenia
背景和目标：心源性猝死是慢性肾脏病患者最常见的死亡原因，其发生主要是由于室性心律失常。在这项研究中，我们旨在调查非透析慢性肾脏病患者室性心律失常的患病率及其发生的相关因素。设计，设置，参与者和测量：这项横断面研究评估了111名慢性肾脏病患者，（估计肾小球滤过率34.7 +/- 16.1 mL/min/1.73 m（2），57 +/- 11.4岁，60%男性，24%糖尿病患者）。通过24小时心电图评估室性心律失常。左心室肥厚（超声心动图），24小时动态血压监测，冠状动脉钙化（多层计算机断层扫描）和实验室参数也evaluated.Results：室性心律失常被发现在35%的患者。21%的患者观察到未控制的高血压，29%的患者观察到收缩功能不全，27%的患者观察到左心室肥大，10%的患者观察到收缩功能不全，49%的患者观察到冠状动脉钙化。室性心律失常患者年龄较大（p
Background and Objectives: Sudden cardiac death is the most common cause of mortality in chronic kidney disease patients, and it occurs mostly due to ventricular arrhythmias. In this study, we aimed at investigating the prevalence of ventricular arrhythmia and the factors associated with its occurrence in nondialyzed chronic kidney disease patients.Design, Setting, Participants and Measurements: This cross-sectional study evaluated 111 chronic kidney disease patients (estimated glomerular filtration rate 34.7 +/- 16.1 mL/min/1.73 m(2), 57 +/- 11.4 years, 60% male, 24% diabetics). Ventricular arrhythmia was assessed by 24-hour electrocardiogram. Left ventricular hypertrophy (echocardiogram), 24-hour ambulatory blood pressure monitoring, and coronary artery calcification (multi-slice computed tomography) and laboratory parameters were also evaluated.Results: Ventricular arrhythmia was found in 35% of the patients. Non-controlled hypertension was observed in 21%, absence of systolic decency in 29%, left ventricular hypertrophy in 27%, systolic dysfunction in 10%, and coronary artery calcification in 49%. Patients with ventricular arrhythmia were older (p