Carbon dioxide supercritical fluid chromatography on a chiral diamide stationary phase for the resolution of D- and L-amino acid derivatives
Carbon dioxide supercritical fluid chromatography on a chiral diamide stationary phase for the resolution of D- and L-amino acid derivatives
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手性二酰胺固定相上的二氧化碳超临界流体色谱用于拆分 D- 和 L- 氨基酸衍生物
DOI：
10.1016/s0021-9673(01)94702-8
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发表时间：
1986
影响因子：
4.1
通讯作者：
M. Senda
中科院分区：
文献类型：
--
作者：
S. Hara;A. Dobashi;Kyoko Kinoshita;T. Hondo;M. Saito;M. Senda
采用超临界二氧化碳移动的流动相，结合极性调节剂，实现了对N-乙酰氨基酸叔丁酯的快速光学拆分。手性（N-甲酰基-L-缬氨酰）丙基硅胶上的正丁基酯不损失对映选择性溶质对映异构体的分析时间小于4分钟。甲醇，乙腈和乙醚被用作极性改性剂，并讨论了它们对对映异构体的分辨率的影响。
A super critical carbon dioxide mobile phase, used in conjunction with polar modifiers, brought about the rapid optical resolution of racemic N-acetylamino acidtert. ≈butyl esters on chiral (N-formyl-l-valylamino)propylsilica without a loss of enantioselectivity The time of analysis of the solute enantiomers was less than 4 min. Methanol, acetonitrile and diethyl ether were used as polar modifiers and their influence on the enantiomer resolution is discussed.