QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology
QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology
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DOI：
10.1093/europace/euv405
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发表时间：
2016-06-01
期刊：
影响因子：
6.1
通讯作者：
Volders, Paul G. A.
中科院分区：
文献类型：
--
作者：
Baumert, Mathias;Porta, Alberto;Volders, Paul G. A.
本共识指南讨论了体表心电图上心跳间期变异性（QTV）的心电图现象。本文介绍了QTV的测量原理、生理基础和临床价值。技术考虑包括QT间期测量和QTV与心率变异性之间的关系。QTV的研究前沿包括对QTV生理学的理解，对QTV与神经活动直接测量之间联系的系统评估，对其他生理变量可变性的QTV依赖性建模，区分QTV与一般T波形状可变性，以及评估QTV对指导治疗的效用。QTV升高似乎是心律失常和心血管死亡的危险标志。它是否能单独或与其他危险因素联合指导治疗仍有待确定。QT间期变异性可能在非侵入性评估强直性交感神经活动中发挥作用。
This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat QT interval variability (QTV) on surface electrocardiograms. The text covers measurement principles, physiological basis, and clinical value of QTV. Technical considerations include QT interval measurement and the relation between QTV and heart rate variability. Research frontiers of QTV include understanding of QTV physiology, systematic evaluation of the link between QTV and direct measures of neural activity, modelling of the QTV dependence on the variability of other physiological variables, distinction between QTV and general T wave shape variability, and assessing of the QTV utility for guiding therapy. Increased QTV appears to be a risk marker of arrhythmic and cardiovascular death. It remains to be established whether it can guide therapy alone or in combination with other risk factors. QT interval variability has a possible role in non-invasive assessment of tonic sympathetic activity.