Overatt atcohot intake, beer, wine, and systemic markers of inflammation in western Europe: Results from three MONICA samples (Augsburg, Gtasgow, Lille)
Overatt atcohot intake, beer, wine, and systemic markers of inflammation in western Europe: Results from three MONICA samples (Augsburg, Gtasgow, Lille)
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DOI：
10.1016/j.ehj.2004.09.032
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发表时间：
2004-12-01
影响因子：
39.3
通讯作者：
Koenig, W
中科院分区：
文献类型：
--
作者：
Imhof, A;Woodward, M;Koenig, W
适度饮酒的抗炎作用已被提出来解释为什么适度饮酒会降低冠心病的风险。我们调查了欧洲三个不同地理区域的总体酒精、啤酒或葡萄酒消费量与全身性炎症标志物之间的关系。方法和结果横断面样本，每个样本代表来自德国、苏格兰和法国的一般人群（MONICA Augsburg 1994/95，2275名男性和2186名女性，25-74岁;格拉斯哥MONICA 1994/95，561/616，25-74岁; MONICA里尔1994/95，581/574，35-64岁）进行了研究。酒精摄入量通过标准化访谈进行评估。通过多元线性回归，计算酒精摄入量类别中C反应蛋白（CRP）、纤维蛋白原、白色血细胞（WBC）计数、血浆粘度（PV）和白蛋白的校正均值，并分别计算啤酒或葡萄酒摄入量。自我报告的中度每日酒精摄入量高达40克与较低浓度的CRP，纤维蛋白原，PV和白细胞计数相比，非饮酒和大量饮酒，即使调整各种潜在的混杂因素。结论适度消费的葡萄酒或啤酒与较低水平的全身炎症标志物在三个不同的欧洲地区，这表明乙醇本身可能是这些饮料潜在抗炎作用的主要原因。(C)2004年由Elsevier Ltd代表欧洲心脏病学会出版。
Aim Anti-inflammatory effects of moderate alcohol consumption have been proposed to explain why moderate alcohol intake lowers coronary heart disease risk. We investigated the relationship between overall alcohol, beer or wine consumption and markers of systemic inflammation in three different geographical areas in Europe.Methods and results Cross-sectional samples, each representative of the general population from Germany, Scotland, and France (MONICA Augsburg 1994/95, 2275 men and 2186 women, 25-74 years; Glasgow MONICA 1994/95, 561/616, 25-74 years, and MONICA Lille 1994/95, 581/574, 35-64 years) were studied. Alcohol intake was assessed by standardized interview. Adjusted means of C-reactive protein (CRP), fibrinogen, white blood cell (WBC) count, plasma viscosity (PV), and albumin were calculated among categories of alcohol intake, and separately for beer or wine consumption, by multiple linear regression. Self-reported moderate daily alcohol intake up to 40 g was associated with lower concentrations of CRP, fibrinogen, PV and WBC count, compared to non-drinking and heavy drinking, even after adjustment for various potential confounders.Conclusions Moderate consumption of either wine or beer is associated with lower levels of systemic inflammatory markers in three different European areas, suggesting that ethanol itself might be largely responsible for the potential anti-inflammatory effects of these beverages. (C) 2004 Published by Elsevier Ltd on behalf of The European Society of Cardiology.